One final point-
One of the factors that must be evaluated before Fmoc manufacturing can be adopted for AOD9604 is that the product must be shown to be at least as free of impurities as that manufactured by other methods. The CZD reference (15/11/11) to this task was stated as "...will be dependent on the Fmoc chemistry producing same or better quality AOD604 as the previously used Boc chemistry...". I think that this statement was mistakenly taken to mean that "better quality AOD604" meant more potent.
That's not what this is all about. All the previous research has been done on AOD9604 manufactured via Boc. The AOD9604 manufactured this way has a certain amount of impurities, as do all manufactured products. In order to use this prior research to support a GRAS application for AOD9604 it would follow that the new product would need to be of equivalent or better purity - otherwise the prior research goes into the waste bin and any GRAS application would be long delayed.
I hope this explanation clears up the issue.
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