ATH 25.0% 0.5¢ alterity therapeutics limited

Rubidium study results are known by Prana's management some 6...

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    Rubidium study results are known by Prana's management some 6 month, paper was sent to the journal 15th of Sep. The results demonstrated that a nerve cell of AD brain could not maintain normal high potassium level inside the nerve cell. This takes usually a lot of energy produced in mitochondria and so the reason to poor performance of the nerve cells in AD was energy crisis and not in the first place accumulation of amyloid.
    Because of this Prana had to change their strategy. They are telling this in the Annular report but it is not so easy to notice. They started the co-operation with Baker Heart and Diabetes researchers and took their 2000 MPACs there.

    Earlier mitochondrial diseases were thought to be some rare childhood brain diseases as Melas, Leigh syndrome or else but now suddenly all organs suffering gradually of poor function could be caused because of poor mitochondria function as cardiac problems, pulmonary problems, kidney problems etc. and there might be some purpose to have these 2000 MPACs ready for all these possible diseases.

    Prana's own special interest neurodegeneration had to be based on a new basis, on the poor performance of mitochondria. Neither was HD anymore a misbalanced metal disease but also a mitochondria disease, most likely, but the metal imbalance was most likely causing the mitochondria problem. But in this new big picture HD was a very small disease and so the partial hold by FDA was not perhaps so big a problem (???).

    Postoperative delirium is an example about how sudden increased need of energy in brain cannot be met and so the patient will get postoperative brain symptoms. Sometimes kidney problems or lung problems also activate because of the same need of energy. This sudden need of energy makes IMO postoperative delirium study a much better study to see if PBT2 will have any help in this energy crisis than just taking minimally symptomatic HD patients as a study population. You need to follow them for years to see if there is any difference in basal ganglions but in postoperative delirium the effect is seen in days if PBT2 works and improves the energy crisis in the whole body. No pencil tests but clear delirium scores anybody will understand.

    I think Prana's strategy has changed and the first results from the energy lab will demonstrate it if you do not believe on the annual report.
 
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