Researchers directed to a lysyl oxidase (LOX) enzyme molecules, called developed some of inhibitor compound. In the process of scar formation, an enzyme that allows the collagen crosslink with each other involved in the wound healing process. Such cross-linking leads to some of the basic biochemical processes be strengthened and lead to scarring.
Many childhood scar on knees and elbows and other parts, although most scars will fade away over time, but such as keloids and burns leave scars of these more serious types tend not to be cured. These scars may cause permanent loss of function of the skin, and in some severe cases, but also gives cause psychological trauma. Now scientists from Australia, are developing new compounds, is expected from the outset to prevent scar formation.
Scientists develop new molecules help prevent scar formation
Researchers at the 252 th American Chemical Society National Meeting and Exposition introduced their latest developments.
In the United States there are tens of thousands of people hospitalized due to burns, there are about 25 million people undergo surgery and other types of keloid scars year. A survey shows that about 7 percent of Americans have Dupuytren's disease, which is a palm area of connective tissue disease caused by tightening.
To solve these problems researchers directed to a lysyl oxidase (LOX) enzyme molecules, called developed some of inhibitor compound. In the process of scar formation, an enzyme that allows the collagen crosslink with each other involved in the wound healing process. Such cross-linking leads to some of the basic biochemical processes be strengthened and lead to scarring.
"In the process of scar formation, the normal structure of the skin can not be restored, resulting in new tissue dysfunction. So our goal from the outset by inhibiting LOX prevent scar formation. We cooperate with Pharmaxis company, we designed a number of new specific small molecule structure can be restored to normal tissue after tissue injury repair. "
The research team used a technique called "Scar-in-a-jar" scarring model checking their molecules. In short, this technology is in cultured human fibroblasts from scar tissue, these cells produce and secrete excess collagen. In this study, researchers from Dupuytren human patient, as well as other keloid scar tissue fibroblasts added LOX inhibitor molecule, followed by the use of two-photon fluorescence microscopy and biochemical and immunological analysis detected cells changes occurred.
Preliminary data suggest that inhibition of LOX can change the structure of collagen, to restore normal structure of the skin. Once the end of the in vitro validation, the researchers detected the effect of these compounds on pigs and mice. If successful animal studies and find a suitable drug candidates, or human clinical trials will be in a few years.
The researchers said their current main goal is to help patients who have severe or extensive scars, but these inhibitor molecules are also expected to be used in cosmetics.
Mobile: Scientists develop new molecules help prevent scar formation
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