Likely Big Pharma can see the writing on the wall in the US...

Likely Big Pharma can see the writing on the wall in the US regarding their dodgy behavior [1].

Doctors and pharmacists favour banning DTC ads altogether. They say the ads drive patients to demand newer, more expansive drugs when more cost-effective choices are available. The practice drives up cost of care and erodes the patient-doctor relationship [1].

Zolpimist (expensive and silly) was rated No2 in a top ten new drugs that doctors hate [2].

In Europe the introduction of additional requirements for Class llb and lll devices mean existing clinical data may need to be revisited, and possibly additional clinical trials may be needed [3].

Experts are calling out the wide acceptance of Sativex being a successful example of drug delivery through the oral mucosa. Sativex acts as an example for other drugs delivered to oral mucosa for systemic absorption and unintentionally washed by saliva flow into the gastro-intestinal tract [4].

A quick check of Anagrelide Safety Data Sheet indicates that it may be irritating to the mucous membrane and upper respiratory tract [5]. Any irritation is important because Chemotherapy and radiation - alone or combined - can cause mouth sores. That's because these cancer treatments are intended to kill rapidly growing cells, such as cancer cells. Some healthy cells in your body also divide and grow rapidly, including the cells that line the inside of your mouth. Unfortunately these healthy cells are also damaged by chemotherapy and radiation [6].

1 https://www.drugwatch.com/featured/big-pharma-marketing/
2 https://www.goodrx.com/blog/drugs-doctors-love-to-hate/
3 https://brandwoodckc.com/european-devices-reforms-how-will-australia-keep-up/
4 https://read.qxmd.com/read/31393180/a-meta-opinion-cannabinoids-delivered-to-oral-mucosa-by-a-spray-for-systemic-absorption-are-rather-ingested-into-gastro-intestinal-tract-the-influences-of-fed-fasting-states
5 https://www.caymanchem.com/msdss/21411m.pdf
6 https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/mouth-sores/art-20045486