Share
675 Posts.
lightbulb Created with Sketch. 150
clock Created with Sketch. 01/03/15
14:24
Share
Originally posted by ammie
↑
gbr, I thought it might be related to whitening.
Expand
Hi ammie,
For decades, P&G Beauty scientists have utilized innovative technologies to research new generations of clinically advanced formulas that will deliver the highest quality skin and hair care products. Scalp and hair follicle expert, Dr. Thomas Dawson, Jr., is an accomplished Principal Scientist in the Beauty Technology department. Dr. Dawson has conducted multiple clinical research trials on the identification of anti-dandruff targets, and has published more than 30 original articles, book chapters and papers which have appeared in journals including Journal of Cosmetic Science, Journal of Investigative Dermatology and Journal of American Academy of Dermatology. As a result of his innovative clinical, scientific and community work in the field of Beauty Technology, Dr. Dawson has earned a P&G Award for exceptional merit in 2001 and the P&G "John Smale" award as P&G's top technologist for 2002. Prior to joining P&G, Dr. Dawson was a Clinical Medical Genetics Fellow at the Duke University Medical Center, where he studied human metabolic disease, the identification of novel disease causing genes, and collaborated in the identification and development of a novel drug to treat Type 2 glycogen storage disease. He was a graduate student and Post-doctoral Fellow at the Lineberger Comprehensive Cancer Center and the University of North Carolina, Chapel Hill, where he studied gene expression and treatment of breast cancer, discovered and analyzed a novel human proto-oncogene, c-mer; and studied reactive oxygen species generation and prevention in orthotopic liver transplantation Thomas l Dawson Phd P&G
Expand
…….would protect a method of diagnosing skin health. The method involves the collection of a skin sample and the detection of biomarkers in the sample that indicate a level of oxidative stress and/or damage. The non-invasive method involves the use of a tape strip with adhesive for collecting a sample which is tested for the presence of myeloperoxide, a protein and pro-inflammatory enzymes that can create an array of potentially damaging reactive oxygen species
Expand
Free radicals are generated in the normal course of metabolism. In other words, whenever we consume food, which is then digested to produce energy. The process of digestion creates free radicals! Free radicals are also created when we breathe! Why do digestion and breathing create free radicals? Because both involve OXYGEN. The oxygen we breathe is carried into cells via the blood, and 99% of it is used to produce energy that we need (the biochemical term for that energy is ATP). This is normal oxygen. It is not reactive. But the remaining 1% of that oxygen enters into a free radical reaction and causes a great deal of destruction everywhere in the body. This kind of oxygen is called Reactive Oxygen Species, which are very harmful types of radicals . How ironic that oxygen is essential to life but at the same time toxic. As long as we breathe and eat, we will sustain free radical damage. It is a lifelong assault that begins at birth and ends at death. This is why we can’t stop aging. We can only slow it down. http://www.justaboutskin.com/anti-aging-skin-care-guide/free-radicals-aging/
Expand
Human skin is sensitive to sunlight, especially to ultraviolet (UV) light, which generates reactive oxygen species (ROS) in dermal cells. This phenomenon is related to disorders or diseases such as stains, freckles, and cancers of the skin When Are Free Radicals Generated? There are many sources of free radicals – external and internal. The biggest external source is UV radiation. Internally, it’s the process of digestion and breathing. During Sun Exposure UV radiation, whether from sun or a tanning bed, is a major trigger of free radicals. When UV light contacts skin, it reacts with oxygen from the air, which causes a destructive, long-lasting free radical chain reaction. SKIN AGES! Sources of Free Radicals Breathing and digestion are internal sources External sources include:
UV radiation Xrays Air pollution / smog Cigarette smoke Alcohol Ozone Heavy metals Rancid fats Drugs Hormones and more What Is the Effect of Free Radicals on Skin? Free radicals damage, weaken, or destroy connective tissue, such as collagen and elastin in skin. They can travel throughout the different layers of skin. UV, for example, can penetrate deep into the dermis where most of collagen lies .
How Can Free Radicals Be Defeated? The first line of defence against free radicals is minimizing exposure to them in the first place. Protecting skin from the sun, smoke, and pollution are activities within our control.This is a hot area in ingredient research right now.
Expand
Assessment and Clinical Implications of Absorption of Sunscreens Across Skin Dr Heather A. E. Benson Abstract Topical sunscreen products are widely used for protection of the skin against the harmful effects of exposure to ultraviolet radiation. Sunscreen agents are incorporated into many every day-use cosmetics as well as so called ‘beach’ products. An ideal sunscreen product will provide effective protection against UV radiation with minimal skin absorption of the active ingredients. There is now clear evidence that a common sunscreen chemical, benzophenone-3, is absorbed systemically following topical application to the skin. Other more lipophilic sunscreens are absorbed into the skin, but penetration to deeper tissues and the cutaneous circulation appears to be limited. However, the extent to which sunscreens that are absorbed into the stratum corneum are absorbed to deeper tissues and the systemic circulation over time is currently unknown. The formulation vehicle in which the sunscreen is presented to the skin has a significant effect on absorption into and through the skin. Alcohol-based formulations appear to increase sunscreen absorption. In addition, some sunscreen chemicals may enhance the skin absorption of other sunscreens when applied in combination. Clearly, further research into the influence of sunscreen and formulation properties on skin absorption could lead to optimal design of sunscreen products with respect to efficacy and minimizing absorption. Despite the extensive use of sunscreen products, there have been few reports of adverse effects, and these tend to be limited to acute dermatitis and allergies. Some recent reports have raised concerns that sunscreen chemicals may damage tissues, particularly in the presence of UV radiation. Further research into the toxicity of sunscreens is urgently required. Given the information currently available and the importance of protecting the skin against sun damage, there is no clear justification for restricting the use of sunscreen products at this time. http://link.springer.com/article/10.2165/00128071-200001040-00003
Expand
.....These repair enzymes are not the complexion equivalent of the morning-after pill. There are actually two types of DNA governing the health of our skin: the DNA in the cell's nucleus, which can be rebuilt with repair enzymes, and the DNA in the cell's mitochondria, which cannot. Both must be protected in order for the skin to function at its absolute best. "One thing they have in common," says Frauke Neuser, PhD, principal scientist at P&G Beauty , "is that it's much easier to try and prevent the damage from happening in the first place than to try to repair it." When mitochondrial DNA is harmed—again, the culprit is usually the sun—the cell's energy metabolism is crippled. "Everything your skin does, needs energy," Neuser says, "so having lower cell energy means collagen production will be slower, as will elastin and natural antioxidant production. It will actually accelerate the signs of aging." And while there's nothing that will erase damage to mitochondrial DNA, a topical ingredient such as Niacinamide —a biologically active form of B3 found in the Olay ProX and Regenerist lines, among others—can essentially act as a cheerleader for the cells' energy levels. Increased energy levels, in turn, might increase the likelihood that your nuclear DNA will be able to muster a plentiful amount of its own natural repair enzymes. It's all connected. DNA repair enzymes may be a game changer when it comes to preventing skin cancer (particularly by reversing actinic keratosis, which previously could be treated only with aggressive laser treatments, prescription creams, or chemical peels), and they will almost certainly provide an extra level of age-defying oomph to anyone's skin-care regimen by enhancing collagen and preventing hyperpigmentation. Still, they should be considered a potent addition to your arsenal rather than a magic bullet. "Unfortunately, there isn't just one thing that will do the whole job," Neuser says. "You need to put together multiple ingredients to get the right protection and efficacy ." http://www.elle.com/beauty/makeup-skin-care/a26140/anti-aging-skin-cancer/
Expand
Now what was the question……. “Olay Regenerist Micro-Sculpting Cream features Niacinamide, which keeps skin cells energized, as well as potent antioxidants and collagen-building pentapeptides”
(20min delay)