Chrisnj,
re your question about who the potential competitors in this space are? I started to get the jitters the more I started to search for who is doing what by searching on "colorectal cancer" in these two web sites:-
* http://www.clinicaltrials.gov/ct2/results?term=colorectal cancer&Search=Search&view=record
* http://search.centerwatch.com/default.aspx?SearchQuery=colorectal cancer
re the statistical significance is marginal, it is a personal preference, some of the p values were good, from memory others were not so good, on balance the more I questioned myself the more I realised that I was simply looking for much stronger results
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