Trying to find definitive link to the recently published...

Trying to find definitive link to the recently published research article early July by Buchhorn R*Department of Paediatrics, Caritas Krankenhaus, Germany

Assessment of Biological Effectiveness of Omega-3-Fatty Supplements Using Holter ECG Analysis in Children

Here

AbstractThe main goal of our work was to check the biological effects of omega 3 fatty acid supplements using 24-hours heart rate variability as an objective parameter.

Methods: We analyzed 24-h heart rate variability in 136 children with a mean age of 10.5±5.0 years who received omega-3-fatty acid supplementation of cause elevated heart rates and reduced heart rate variability due to attention deficit disorder, heart disease, short stature, obesity and somatoform disorders. 116 children received different product from a retail store that are generally stabilized with Alpha-Tocopheryl Phosphate Mixture and 20 children received a product that certainly didn’t include it.

Results: We found highly significant effects of omega 3 fatty acid supplements on heart rate both by day and at night as recently published. However, there is no heart rate lowering effect of the supplement without Alpha-Tocopheryl Phosphate Mixture. The heart rate lowering effect of omega-3-fatty acid supplements depends on heart rate at baseline, but not on the different indications and sex in childhood.

Conclusion: Bioavailability of omega-3-fatty acid supplements may explain the inconsistency of the clinical benefit of omega-3-fatty acid supplementation. We propose the manufacturer to proof the biological effectiveness of omega-3-fatty supplements using Holter ECG analysis in children.

Definitely worth a read and specifically refers to TPM with reference (amongst others) to AVE paper published 2017 on Omega 3 that I'd seen before.

Not aware of AVE TPM enhanced Omega 3 product so sourced elsewhere?

Libinaki R, Gavin PD. Changes in Bioavailability of Omega-3 (DHA) through Alpha-Tocopheryl Phosphate Mixture (TPM) after Oral Administration in Rats. Nutrients. 2017; 9.