G'day kpax - long time no hear!
On the topic of mTOR, protein clumping and clearing out... I've been looking at some early work that implicates mTOR as a potential therapeutic target in Duchenne muscular dystrophy - the similarities with MND are startling. See for example: https://www.nature.com/articles/cddis2012159
but with a quick look about you'll find several other studies. Duchenne's usually affects boys and leads to signfiicant muscle wastage, usually a wheelchair by around 10 years of age and a life expectancy in the late 20's. As with MND, there's currently no effective treatment - orphan drug status??
I expect PAA's IP in relation to neurodegenerative disorders would address this application.
It seems the possibilities for this molecule are vast.
Roll on GMP tablets...
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