Because it is a relatively small IST at this point of which Onyx...

Because it is a relatively small IST at this point of which Onyx have many to explore how they work in combination it's not a large Phase III trial like Endeavour for example with 800 patients - that might come at some time in the future but until the IST has provided evidence that may warrant them to advance it remains as is.


Investigator Sponsored Trials
Onyx is committed to advancing scientific and medical understanding of our therapies to enhance patient care through support of investigators’ independent research. Through our Investigator Sponsored Trial (IST) program, Onyx supports investigators who have interest in further exploring and gaining new and valuable information about the appropriate use of our treatments. Investigators and their sponsoring institution independently generate and submit a research and support plan to the Onyx IST review committee, and assume all sponsor responsibilities if the study is approved.

Onyx support of ISTs is provided in the form of study drug supply and may include research funding. The Onyx IST program is global, and currently considers research proposals relating to carfilzomib and, in select cases, earlier stage pipeline compounds.