Other Cancers & Preventative

Genomic studies show the complex development of cancers in the brain, that have mutated away from the primary cancer.

GDC 0084 PI3k inhibitor is tasked with the blockage of these much more complex mutations, chromosomal rearrangements and gene amplification in the brain. (as compared to the original cancer source in the body)

A diverse range of stakeholders are keenly awaiting the very first results in human studies for this drug in brain metastases. (BM results soon, will follow successful Phase 2 studies in another type of brain cancer disease called glioblastoma.

GDC0084 selectively inhibits both alpha and beta isoforms of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (p110a & b).

Following the comment last week from the CEO that this drug works outside the brain (and from what we know already about the drug)....it would seem there is opportunity for this drug to go head to head with existing approved multi- billion dollar PI3K drugs. eg (breast, lung)

The major difference though....and where other PI3K drugs can't compete, is the brain metastases preventative abilities of GDC 0084.

Of interest, here is a list (at very bottom) of sometimes expensive drugs, used as a breast cancer preventive measures. Cancer presentation and the drastic actions that have been taken by some, is a big issue in society.

Only GDC 0084 has the ability to work as a brain PI3K preventative drug.....should, which seems very possible, it is also used outside of the CNS.

https://www.drugs.com/condition/prevention-of-breast-cancer.html