Moderna/Merck mRNA vaccine trial was for melanoma.
Results 'promising' results P2. 44% reduced recurrence compared to Keytruda mono.
Check out Immutep/Merck TACTI-Mel P1 trial. Oct 2018
Efti and Keytruda
Results promising too (small cohort 24 patients).
Disease control - 66%
Patients tumour shrinkage - 50%
NB - melanoma is particularly immuno-responsive and a crowded space for approved therapies.
Poster presentation of TACTI-mel
Conclusion section:-
2 patients with complete response
Supports hypotheses that combining APC activator with checkpoint inhibitor- synergy and clinical benefit
Further investigation of this combination is ongoing in NSCLC and HNSCC
Therefore focus moved to NSCLC/HNSCC as higher priority unmet need.
Efti - APC activator could be the idea partner to help turn 'cold' solid tumours 'hot' and boost performance of primary ICI's, chemo and others, including vaccine/virus drug candidates in clinical development.
Lag-3 and efti is only at the beginning of its commercial journey.
Overnight Market report, page-1254
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