Unless I am misunderstanding your y-axis, looks a little unoptimistic on the REM-L mortality, they achieved <17% in the compassionate use trial...
Its all on the prior used in the Bayesian method and there is no way of getting information on that. I am hoping given their knowledge of death rates in severe patients it will be a bit less onerous than Kervio's sceptical prior and putting stop at 45% recruitment at a 40% probability myself and a stop at 60% recruitment at 80% failing that, myself for various arguments made on this and other threads.
The only drug/treatment really with any semi-proven success is dexamethasone and the suggestion is that if given too early it can actually impede patients immunity systems rather than aid them. Proning seems the only clearly beneficial medical contribution so far in severe ventilated patients.
What a joke for advanced societies that rolling patients is all we can add to standard of care. If you think I am being harsh there were excellent papers post SARS talking about the potential rise of RNA viruses and the need for treatments as long ago as 2005:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294426/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128319/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128468/
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