PAA

2.50%

20.5¢ pharmaust limited

Hey Kpax,Thank you for your research.Could MPL help prevent...

First 496 Last

Share
Profile

Follow
Havenots

659 Posts.

507

22/02/22

17:44

Post #: 59740365
Share

Originally posted by kpax: ↑

Hi All,

I have been doing some research with another HC member.

We may have found something that to date no one has quantified in the pharmacodynamics of MPL.

Now, we know that mTOR inhibition is the principle action in reducing B cell Lymphoma in canines.

What scientists don't know specifically is why.

We feel it is to do with the TLR receptors in the body. They are Toll Like Receptors that when activated causes a mutant B cell which then grows to be a tumour ( immune system mediated cancer) . TLR receptors are your first line of immune defence. I have posted before on the bodies response to SARS, to some people it is a minor type presentation of a flu, to others it's ICU. Dependant on the immune inflammatory response.

What is interesting is that if you cross reference MPL with TLR you will not find any data.

Onto SARS-Cov-2 , the TLR sub set 2 is a cytokines inflammatory process which causes the mortality and morbidity.

mTOR inhibitors mediate TLR-2.

If we can control TLR-2 over activation we have a definitive handle on this.

MPL is a fourth generation rapalog of Rapamycin . It has far less side effects of the first generations.

Ref : mTORC1 signalling controls TLR-2 mediated T cell activation by inducing Tirap expression. Imanishi 2021.

Ref : TLR-2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines. Zheng 2021

Ref : Toll like receptors in the pathogenesis of human B cell malignancies. Isaza-Correa 2014.

We believe there is a substantial link , initially I believed , that MPL had to do with cell cycle arrest on the GO phase of replication of the SARS-Cov-2 cell in the body , time changes so does knowledge.

This is one awesome drug to study and I own a part of it. So do you. Happy days ahead.

Expand

Hey Kpax,

Thank you for your research.

Could MPL help prevent pneumonia as well?

Havenots

Not long now….

PAA Price at posting: 9.5¢ Sentiment: Buy Disclosure: Held
6 Upvote

0 Great analysis

Reply

Top Stories

STK

5.6g/t gold intercept at Serbia's Rogozna supports Strickland's hopes for high-grade core

4DX

4DMedical lands Philips US reseller deal with eye to Veterans Affairs' market post-lung damage

The winners & losers on market if negative gearing were gone

COD

Coda Minerals (ASX:COD) enters rights issue to further exploration in South Australia

ACW

Actinogen Medical ramps up Alzheimer’s treatment trials, targeting fast-track global approvals

ESR

Estrella first foreign entity to win tenements in Timor-Leste under new laws ahead of 2025 tenders

ZER

Zeta Resources seeks to resolve the Panoramic takeover story

NAM

ACCC seeks Olam divestments before its acquisition of Namoi Cotton can go ahead

The market's shrugged at China's stimulus measures all year. Why is this one different?

DEG

HotCopper users muse on De Grey's denial of Agnico Eagle takeover bid – but who are Agnico?

There are more pages in this discussion • 971 more messages in this thread...

First 496 Last

Add PAA (ASX) to my watchlist

(20min delay)
Last 20.5¢		Change 0.005(2.50%)		Mkt cap ! $99.71M

Open	High	Low	Value	Volume
20.5¢	20.5¢	20.0¢	$66.86K	327.5K

Buyers (Bids)

No.	Vol.	Price($)
3	27750	20.0¢

Sellers (Offers)

Price($)	Vol.	No.
20.5¢	84999	3

View Market Depth

No.	Vol.	Price($)
3	27750	0.200
3	167702	0.195
4	192741	0.190
5	139546	0.185
6	264330	0.180

Price($)	Vol.	No.
0.205	84999	3
0.210	262500	5
0.215	261982	8
0.220	679543	10
0.225	592637	3

Last trade - 14.42pm 27/09/2024 (20 minute delay)

PAA (ASX) Chart

Hey Kpax,Thank you for your research.Could MPL help prevent...

5.6g/t gold intercept at Serbia's Rogozna supports Strickland's hopes for high-grade core

4DMedical lands Philips US reseller deal with eye to Veterans Affairs' market post-lung damage

The winners & losers on market if negative gearing were gone

Coda Minerals (ASX:COD) enters rights issue to further exploration in South Australia

Actinogen Medical ramps up Alzheimer’s treatment trials, targeting fast-track global approvals

Estrella first foreign entity to win tenements in Timor-Leste under new laws ahead of 2025 tenders

Zeta Resources seeks to resolve the Panoramic takeover story

ACCC seeks Olam divestments before its acquisition of Namoi Cotton can go ahead

The market's shrugged at China's stimulus measures all year. Why is this one different?

HotCopper users muse on De Grey's denial of Agnico Eagle takeover bid – but who are Agnico?

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

Hey Kpax,Thank you for your research.Could MPL help prevent...

Top Stories

5.6g/t gold intercept at Serbia's Rogozna supports Strickland's hopes for high-grade core

4DMedical lands Philips US reseller deal with eye to Veterans Affairs' market post-lung damage

The winners & losers on market if negative gearing were gone

Coda Minerals (ASX:COD) enters rights issue to further exploration in South Australia

Actinogen Medical ramps up Alzheimer’s treatment trials, targeting fast-track global approvals

Estrella first foreign entity to win tenements in Timor-Leste under new laws ahead of 2025 tenders

Zeta Resources seeks to resolve the Panoramic takeover story

ACCC seeks Olam divestments before its acquisition of Namoi Cotton can go ahead

The market's shrugged at China's stimulus measures all year. Why is this one different?

HotCopper users muse on De Grey's denial of Agnico Eagle takeover bid – but who are Agnico?

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News