I took a trip down memory lane this afternoon and re-read this paper that started the journey for monepantel.
2014 / Uni of NSW/St George Hospital.
While it was analysing monepantel in ovarian cancer cell lines, it revealed the role MPL plays in suppression of the mTOR/p70S6K signalling pathway, and provided the first evidence to show that MPL triggers autophagy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163620/
Well worth another read for those who are new to PAA and are delving into the science.
PAA, A New Dawn , FDA ODD Approval and Entering Phase II MND Trial, page-569
-
- There are more pages in this discussion • 410 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Add PAA (ASX) to my watchlist
 (20min delay)
|
|||||
|
Last
17.5¢ |
Change
0.000(0.00%) |
Mkt cap ! $85.12M | |||
| Open | High | Low | Value | Volume |
| 18.0¢ | 18.0¢ | 17.0¢ | $141.2K | 801.7K |
Buyers (Bids)
| No. | Vol. | Price($) |
|---|---|---|
| 11 | 537419 | 17.0¢ |
Sellers (Offers)
| Price($) | Vol. | No. |
|---|---|---|
| 18.0¢ | 140000 | 3 |
View Market Depth
| Last trade - 16.10pm 06/09/2024 (20 minute delay) ? |
| PAA (ASX) Chart |