PAR and ... no way... it can’t be...
I'll fill in that gap in a sec. I've written quite a few articles on PAR now, I've received some great comments, feedback and encouragement and I thank you guys for that, it does urge me on for sure......I've only been on HC for like 9 months...There have been some discoveries that I've come across while researching into our great company and the 'magic' drug, iPPS.
Mate, I gotta tell you, this post is potentially BIG. So big it might eclipse quite a few of my other posts combined....Now just before we get into it...tonight I'm breaking this mind boggling research into two parts, non technical summary Part 1, and Part 2 for the meatier technical summary for those who crave more and want to digest extra details and the more sciency stuff...Please do enjoy:
PART 1Yes...Im talking about PAR and Cancer. Now before you all start thinking I've lost me marbles and Im as daft as a Mad Hatter...I of course must throw some good disclaimers at you....I'm not saying that we can cure cancer..I'm not even saying it might be relevant or make a difference. I AM saying that there is SOME research out there for an ASSOCIATION possibly, that we may to some degree alleviate symptoms or in
some instances possibly address some part of cancerous type cells? I AM saying that further scientific research needs to be conducted in this field. I also am telling you to do your
own research, don't rely on anything I put to you but keep your ears and eyes open, one day this could be a game changer.
Mozz has lost his marbles? We need some evidence...and now......Ok ok Mozzarc my friend, we need some proof here bud, you can't just go shouting this stuff from the rooftops without some hard evidence...
Paradigmers, now here is a statement for you all if ever I saw one...
“in vivo, Pentosan prolonged survival of male rats injected with highly metastatic cells”.
1What? Not only that, I bring to you this one, and this is from a
different source.:
“in vitro, pentosan is an inhibitor of a variety of heparin – binding growth factors released from tumour cells”.
2Let’s dissect this one some more...
In vivo = within the body of living organisms
3In vitvo = outside the body
Herparin - well like the NGF which we now know more about (new investors please refer to reference 7 in reference list for some back-ground info), it works in a similar fashion and involves prolonging the clotting time of blood.
Yes there is some sort of chance that our old friend IPPS perhaps can have
some influence on the terribly awful condition of cancer.
Where the heck did I see this quote? A bit like those books
“Chose your own adventure”, while researching one topic I found myself heading down all sorts of different paths... I was simply wanting to try and grab the chemical properties of the PPS molecule and look where I ended up!
One starts in one research field but ends up traversing though so many other stories, a bit like those Choose Your own Adventure books I read as a kidOk you want more don't you? No steak knives here, just possible future 'presents' for us in terms of share price, well like you, I can only speculate on the share price and where it might head in the future...Here is yet another separate study conducted by
S J Elliot and others back in 2003
4. Ok some back ground first, it gets a bit technical so bare with me, will try and simplify it as much as I can.
1) Prostrate - what is it? The prostate is a walnut-sized gland located between the bladder and the penis. The prostate is just in front of the rectum. The urethra runs through the center of the prostate, from the bladder to the penis, letting urine flow out of the body. The prostate secretes fluid that nourishes and protects sperm. During ejaculation, the prostate squeezes this fluid into the urethra, and it’s expelled with sperm as semen.
5.5 2) What can go wrong?Prostatitis: Inflammation of the prostate, sometimes caused by infection. It is typically treated with antibiotics.Enlarged prostate: Called benign prostatic hypertrophy or BPH, prostate growth affects virtually all men over 50. Symptoms of difficult urination tend to increase with age. Medicines or surgery can treat BPH.Prostate cancer: It’s the most common form of cancer in men (besides skin cancer), but only one in 41 men die from prostate cancer. Surgery, radiation, hormone therapy, and chemotherapy can be used to treat prostate cancer. Some men choose to delay treatment, which is called watchful waiting.
5.5 3)What is one biomarker or biomarker like behaviour that can be searched for to indicate the presence of cancer? Collagen. For more info on this check out reference 5.6.
4) What is Collagen?Think of Collagen as the scaffolding that provides strength and structure in the human body. Need more info, head to reference 5.7. Perhaps like Cholesterol, there is good and bad collagen.
5) What is the effect of PPS on this protein?Well head to the abstract of Elliot's work in reference 4 but the summary in simpleton Mozzarc terms is that PPS decreases the proliferation (read; spread) and production of the bad collagen.
Do check out the full abstract by following reference 4 below , I read this in conjunction with reference 5 (Another study that investigates the role of collagen in this area) to put the above 5 questions and answers together. Reference 4 is not a long read but quite a technical one, though worth pursuing to get further colour on this incredible discovery. I post the amazing conclusion here for your perusal in reference to Prostrate and cancer:
" In conclusion, we found that the administration of PPS decreased proliferation as well as ECM production in prostate smooth muscle. Since smooth muscle proliferation and ECM are involved in the pathophysiology of BPH, PPS may have therapeutic potential."BPH stands for Benign Prostrate Hyperplasia.Smooth Muscle are involuntary contractile fibrils. Ie Gut Muscles, Internal Organs etc.
5In a very simplified summary and just using my simple interpretation, the researchers cut out some of the related prostrate cells and in the control they did nothing and in the other they added PPS. The PPS resulted in decreased levels of collagen which may be an indication of the positive effects PPS
may have in such situations and in certain cases. At the end of it, my point is that further research should be done to follow and discover if PPS has any merit and therapeutic benefits in these areas.
PART 2I've given you quite enough to do your own research but like those ads say...but wait, there is more....
Fellstrom et al in 1987 tried Pentosan in both formats, injectable AND oral. As we know, and as he surmised, the bio availability (uptake) was only 0.5 - 1% in tablet form. He stated that the observations were "Only 8% of the intravenous does was recovered in the urine" suggesting that there was "extensive metabolism".
6 It was noted that in mice when they were dosed there was no "Mutagencity" and no "chromosomal damage". No AE's consistent with what we have experienced in human trials.
So on to the scientific observations;
1) "Treatment with pentosan prevents the progression of nephropathy in streptozotocin-induced diabetes in ageing C57B6 mice by decreasing albuminuria, renal macrophage infiltration, and expression of tumour necrosis factor-α "
82) "subcutaneous growth of tumours from all cell lines in athymic nude mice was inhibited in a dose-dependent fashion by daily intraperitoneal injections of pentosan"
2 More evidence from yet another, separate study:
Rha et al. (1997) reported that "growth of gastric-cancer cell lines expressing midkine, a novel heparin-binding growth/differentiation factor, was inhibited by pentosan, which was described as a heparin-binding blocking agent'.
9Ok now we dive into the real science...admittedly its beyond a mere mortal like me, but just take a look at Figure 1 below.
Figure 1 There is a fair amount involved in our bodies...its complex...but a lot of these terms we have seen mentioned in past PAR announcements and more will no doubt come as we get those peer reviewed docs.10In the case of "tumor cell lines established from the breast, prostate, epidermoid and lungcarcinomas"
2, It was found that our little PPS " inhibited this stimulus".What is the scientific implication of this? Don't rely on me, lets go to the study:
Snapshot from study by J Natl Cancer Inst. 1992 Nov 18;84(22):1716-24 2Look, I ain't gonna blow me own trumpet, finally I'm just a retail investor with a vested interest in PAR...I
will go beyond the normal superficial research to get answers and to make sure, albeit mainly for me, but happy to share with you too, that our investment is sound, it is capable of more AND it is as insured as much as can be against AE's both in terms of Medical and Financial risk. This means I cannot and will not simply rely on JUST the www...so I went to a trusted PAR source...I'm not allowed to quote and have been advised not to do so...so you will have to take it from me...if that's too much of a leap of faith then simply ignore the next paragraph..
I asked "Why in the world hasn't any one else acted on these amazing results? These studies outlined above were conducted years and years ago!". The answer? Well mainly because most cancer fighting companies concentrate on the well proven technology of Chemotherapy. No one really has investigated in depth and now no one really has the rights to do so (in my opinion) apart from us at least from a commercial production stance utilising iPPS. Yes in MY opinions this will one day will come up on the PAR radar and the source smiled and agreed with me.
Another caveat, there is some discussion on how experiments in animals may or may not translate smoothly into humans. All I am leaving you with today is the
possibility of our Paradigm one day in the future, maybe distant future, of doing
some research in this groundbreaking area. I'm not a scientist or even employed in the Medical field, however, IMHO there is so much more to the story and wonderful actions of iPPS that even you and I know about. Forget 1000 inflammatory indications and patents, just a handful of such as these indications and all of a sudden we could be in a different world.
Paradigmers, bring on the future.
REFERENCES1
https://www.ncbi.nlm.nih.gov/books/NBK350418/2
https://www.ncbi.nlm.nih.gov/pubmed/12791863
https://www.lexico.com/en/definition/in_vivo4
https://www.ncbi.nlm.nih.gov/pubmed/128063725
https://www.lexico.com/en/definition/smooth_muscle5.5
https://www.webmd.com/men/picture-of-the-prostate#15.6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404286/5.7
https://www.medicalnewstoday.com/articles/262881.php6.
https://www.ncbi.nlm.nih.gov/books/NBK350418/7. Paradigm Announcement - MOA -
https://www.asx.com.au/asxpdf/20190930/pdf/449016vj9d91qs.pdf8.
https://www.ncbi.nlm.nih.gov/pubmed/218082389.
https://www.sciencedirect.com/science/article/abs/pii/S030438359700215210.
https://en.wikipedia.org/wiki/Paracrine_signaling#/media/File:Signal_transduction_pathways.png
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