Thanks Mozz, it's a good reminder of what's still possible with...

Thanks Mozz, it's a good reminder of what's still possible with extraordinary level of patience plus a fair bit of luck. Whilst I'm still looking to see if PR becomes dogmatic over chasing DMOAD post FDA engagement versus getting us to market, I'd share this investment insight (which I saved from 2018) given I feel it has some level of relevance to most of us regulars on this thread (if not HC).

Paying Too Much Attention
Our most meaningful investment milestones are decades away, but our attention is monopolized by the moment. Paying too much attention to our investments today can put us at risk of missing goals that are years away.One of the chief side effects of monitoring our investments too closely is that it fuels our aversion to loss. [3] Loss-aversion is but one suitcase among our abundant evolutionary baggage. The theory is that we feel far greater pain from losses than we experience pleasure from gains of equal magnitude. The tie to evolution is that Fred Flintstone had far greater incentive to avoid being mauled by a saber-toothed tiger than to order another oversize rack of ribs from his already-toppled car.

Loss aversion can have a meaningful impact on investor behavior. In “Myopic Loss Aversion and the Equity Premium Puzzle,” [4] Shlomo Benartzi and Richard Thaler demonstrated that the disconnect between the duration of investor’s goals (retiring 30 years from now, for example) and the frequency with which they monitor their portfolios (typically at least once a year) leads to a behavior they coined “myopic loss aversion.” The likelihood of losses in any given one-year period is far greater than the probability of losing money over a longer horizon. But the authors found that annual reviews led investors to behave as if their investment horizon was a year out and not 10 or 20 or 30. This leads many to take less risk (by allocating less to stocks, for example) than is necessary to meet their longer-dated goals. The best way to shake this behavior is to simply stop paying so much attention to the markets and our portfolios. I am a firm believer in an approach to portfolio monitoring and maintenance that borders on benign neglect. There is so much noise in the markets that the signal typically fades into the background. Tuning out the noise will also help to diminish the illusion of control and recency bias. In recent years, I personally have made a habit of only looking at my own investments once every few months or so. I’ve found that every time I turn up the volume knob on the market’s noise-making apparatus, it’s tempted me to tinker with my portfolio. While it’s tough to put the market on mute, I think we’d all be better served by tuning out a bit more often.

https://www.morningstar.com/etfs/3-investing-mistakes-avoid