Well yes they do have a legal responsibility, here are some guidelines:
It needs to be done if its appropriate and there are no other viable official alternatives etc.
Weighing up of cost/benefit analysis is also a consideration to the patient etc.
Sure some Docs wouldn't be prepared to do it...but it is allowed in light of the above points and considerations.
Check out below references for additional info.
REFERENCES
1) https://www.mdanational.com.au/advice-and-support/library/articles-and-case-studies/2019/11/off-label-prescribing-what-you-need-to-know#:~:text=In%20summary,exhausted%2C%20not%20tolerated%20or%20unsuitable.
2) https://www.anzca.edu.au/resources/professional-documents/guidelines/use-of-off-label-or-drugs-beyond-licence-in-pain-m
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