PAR. SP, page-194

Bring on those results! (End of the year)....
Its already encouraging that they are moving down the Age stratum in the Brazil study...no safety issues so far...

Here is a sample of what we may see, this study involving a study comapring Oral PPS and our wonderful iPPS in dogs published in 2016:

GAG Analysis in PPS Treated MPS I Dogs

Total GAGs were measured in urine and tissues of age-matched normal, untreated and PPS treated MPS I dogs. Total GAGs were significantly reduced in all treated animals when compared to untreated, with greater reductions seen in the animals treated by subQ PPS (Fig 2). To confirm these findings, mass spectrometry was performed (Fig 3). Heparan sulfate disaccharides (DiHS-OS, DiHS-6S and DiHS-NS) and the dermatan sulfate disaccharide (Di-6S) were each reduced in the PPS treated animals. The greatest response was seen with Di-6S, a primary GAG fragment that also accumulates in MPS VI.

The line from above that does it for me....



"Total GAGs were significantly reduced in all treated animals when compared to untreated, with greater reductions seen in the animals treated by subQ PPS"




Graphically:














Reference:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827827/