Paradigm Competition, page-3

It's a pass from me...
Part immunosuppressant...
Intra articular and a couple of warnings:


"Serious and sometimes fatal infections may occur during treatment with canakinumab. Call your doctor right away if you have signs of infection such as: fever, chills, sweating, tiredness, cough, shortness of breath, skin sores, warm or painful areas on your body, diarrhea, stomach pain, or weight loss".¹



"Canakinumab can weaken your immune system. Your blood may need to be tested often". ¹



(My emphasis added below)


"Innate immunity drives atherogenesis and cardiovascular risk, but also participates in host defenses against pathogens. The Canakinumab Anti-Inflammatory Thrombosis Outcomes Trial (CANTOS) showed that treatment with the anti-interleukin-1β antibody canakinumab improved cardiovascular outcomes, but associated with a small increase in fatal infections".²




Not saying it doesn't have a place (?)..but I know what I'd wait for and which drug I'd be trying out first...





DYOR



REF
1) https://www.drugs.com/mtm/canakinumab.html#:~:text=Warnings-,Serious%20and%20sometimes%20fatal%20infections%20may%20occur%20during%20treatment%20with,stomach%20pain%2C%20or%20weight%20loss.
2) https://academic.oup.com/eurheartj/article/39/suppl_1/ehy564.358/5080115