Improvements in Cancer Treatment gives a clear explanation of why rectal administration is the key to making isoflavones work on a consistent basis, as this route bypasses the liver and the gut and therefore avoids conjugation; and why it is essential to dissolve an isoflavone in a hydrophobic or lipophilic base, rather than simply mixing them together.
The international search report states that dissolving idronoxil in the base is an inventive step.
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