Patent, page-88

Patents last for 20 years (plus extensions)
Patent chains are updated for improvements is manufacturing, material composition, application etc
Patents can also have their term extended in many jurisdictions by at least the time it took to settle the patent, but up to 5 years.
Trade secrets are real. I know some pretty smart folk who's patents have a spanner here and there to make building from the patent impossible without putting the time and effort into reverse engineering the product the hard way..

I reckon we're good until at least the mid 2030's (based on the patent chain below), though I expect the product will have many improvements and iterations along the way; extending patents much further.

Fes

BTW... Integra's initial lead patent for the scaffold was approved in 1996

INTEGRA PATENT

• Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
  Patent number: 5489304

  Abstract: The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.

  Type: Grant

  Filed: April 19, 1994

  Date of Patent: February 6, 1996

  Assignees: Brigham & Women's Hospital, Shriners Hospital for Crippled Children, Massachusetts Institute of Technology, Integra LifeSciences, Corporation

  Inventors: Dennis P. Orgill, Charles E. Butler, Mark Barlow, Scott Ritterbush, Ioannis V. Yannas, Carolyn C. Compton

Patents Assigned to Polynovo Biomaterials Pty Limited

• Tissue repair laminates
  Patent number: 10898614

  Abstract: There are provided tissue repair laminates which promote cellular in-growth but also prevent or mitigate tissue adhesion. The laminates comprise a biodegradable polyurethane foam layer which facilitates cellular infiltration and a polyurethane barrier layer which is non-adhesive to tissue. The laminates resist shrinkage under in vivo conditions and possess desirable mechanical properties. The laminates find use in, for example, the repair of herniated tissue, particularly, but not limited to hernias in the abdominal wall.

  Type: Grant

  Filed: December 21, 2018

  Date of Patent: January 26, 2021

  Assignee: POLYNOVO BIOMATERIALS PTY LIMITED

  Inventor: Timothy Graeme Moore
• Chain extenders
  Patent number: 10844158

  Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.

  Type: Grant

  Filed: June 1, 2017

  Date of Patent: November 24, 2020

  Assignee: POLYNOVO BIOMATERIALS PTY LIMITED

  Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
• Chain extenders
  Patent number: 9695268

  Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.

  Type: Grant

  Filed: December 17, 2014

  Date of Patent: July 4, 2017

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
• Biodegradable polyurethane and polyurethane ureas
  Patent number: 9540478

  Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.

  Type: Grant

  Filed: April 14, 2015

  Date of Patent: January 10, 2017

  Assignee: POLYNOVO BIOMATERIALS PTY. LIMITED

  Inventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake
• BIODEGRADABLE POLYURETHANE AND POLYURETHANE UREAS
  Publication number: 20150246994

  Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.

  Type: Application

  Filed: April 14, 2015

  Publication date: September 3, 2015

  Applicant: Polynovo Biomaterials Pty Limited

  Inventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake
• Biodegradable polyurethane/urea compositions
  Patent number: 9084827

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Grant

  Filed: December 6, 2013

  Date of Patent: July 21, 2015

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
• Biocompatible polymer compositions for dual or multi staged curing
  Patent number: 8729202

  Abstract: The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required.

  Type: Grant

  Filed: March 3, 2005

  Date of Patent: May 20, 2014

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Pathiraja Arachchillage Gunatillake
• BIODEGRADABLE POLYURETHANE/UREA COMPOSITIONS
  Publication number: 20140099277

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Application

  Filed: December 6, 2013

  Publication date: April 10, 2014

  Applicant: POLYNOVO BIOMATERIALS PTY LIMITED

  Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
• Biodegradable polyurethane/urea compositions
  Patent number: 8628761

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Grant

  Filed: October 31, 2012

  Date of Patent: January 14, 2014

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
• Biodegradable polyurethane/urea compositions
  Patent number: 8529880

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Grant

  Filed: October 31, 2012

  Date of Patent: September 10, 2013

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
• BIODEGRADABLE POLYURETHANE/UREA COMPOSITIONS
  Publication number: 20130150964

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Application

  Filed: October 31, 2012

  Publication date: June 13, 2013

  Applicant: POLYNOVO BIOMATERIALS PTY LIMITED

  Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
• Biocompatible polymer compositions
  Patent number: 8445581

  Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.

  Type: Grant

  Filed: August 2, 2007

  Date of Patent: May 21, 2013

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
• BIODEGRADABLE POLYURETHANE/UREA COMPOSITIONS
  Publication number: 20130121969

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Application

  Filed: October 31, 2012

  Publication date: May 16, 2013

  Applicant: POLYNOVO BIOMATERIALS PTY LIMITED

  Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
• Biodegradable polyurethane/urea compositions
  Patent number: 8343472

  Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

  Type: Grant

  Filed: July 23, 2003

  Date of Patent: January 1, 2013

  Assignee: Polynovo Biomaterials PTY Limited

  Inventors: Raju Adhikari, Pathiraja A. Gunatillake
• CHAIN EXTENDERS
  Publication number: 20110287102

  Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.

  Type: Application

  Filed: June 20, 2011

  Publication date: November 24, 2011

  Applicant: Polynovo Biomaterials Pty Limited

  Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
• Chain extenders
  Patent number: 7964696

  Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.

  Type: Grant

  Filed: September 20, 2006

  Date of Patent: June 21, 2011

  Assignee: Polynovo Biomaterials Pty Limited

  Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
• BIOOCOMPATIBLE POLYMER COMPOSITIONS
  Publication number: 20090324675

  Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.

  Type: Application

  Filed: August 2, 2007

  Publication date: December 31, 2009

  Applicant: POLYNOVO BIOMATERIALS PTY LIMITED

  Inventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb