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RedfacesPardon my ignorance, I am also new to this,and i am...

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    Redfaces
    Pardon my ignorance, I am also new to this,and i am quite happy to stand corrected but I am trying to reconcile your 1000 patients required for the trial, to that of the prof who said that orphan status can be granted to a company developing a drug treatment for a disease with only small prevalence in the population.
    So if there is a small prevalance in the population, will the FDA accept less than the "several hundred to several thousand "
    I acknowledge that a small prevalence in the USA may still be a large number.

    Thanks in anticipation
 
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