The research papers:
PERSPECTIVES AND COMMENTARY
PBT2 pumps up polymyxins
By Michael Funk, et al. | Nov 21st, 2020
b'Antibiotic Resistance PBT2 pumps up polymyxins Melissa Norton Bacterial resistance to antibiotics is a growing worldwide problem, and Enterobacterales with resistance to the polymyxin class of antibiotics are a critical threat. De Oliveira et al. repurposed a hydroxyquinoline compound called PBT2, currently in phase 2 clinical trials for neurodegenerative diseases, to break polymyxin antibiotic resistance in four different Gram-negative pathogens, including Klebsiella pneumoniae and Pseudomonas aeruginosa. In vitro, treatment with PBT2 disrupted the abundance of zinc and iron in the resistant bacteria, whereas in immunocompetent septic mice, PBT2 combined with polymyxins resulted in improved survival with reduced bacterial dissemination.
- DOI: 10.1126/science.370.6519.926-b
- Science Vol. 370, No. 6519
RESEARCH AND REVIEWS
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis
By David M. P. De Oliveira, et al. | Nov 19th, 2020
In vitro, treatment with PBT2 disrupted the abundance of zinc and iron in the resistant bacteria, whereas in immunocompetent septic mice, PBT2 combined with polymyxins resulted in improved survival with reduced bacterial dissemination. ... Table 1 PBT2 resensitizes polymyxin-resistant Gram-negative pathogens to polymyxin class antibiotics. ... MIC assays were undertaken in the absence (untreated) or presence of PBT2.
- DOI: 10.1126/scitranslmed.abb3791
- Science Translational Medicine Vol. 12, No. 570
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