PBT434 inhibits alpha- synuclein in the brain., page-26

That is very interesting kpax, if 75% of ice users are going to get Parkinson's sadly that could contribute to an even faster increasing incidence of PD. Why would anyone take those drugs?

[The 2016 National Drug Strategy Household Survey found that 6.3% or 1.3 million Australians over the age of 14 had ever used methamphetamine (including ice, speed or base) and 1.4% reported recent use (in the past 12 months).]

A-Syn is not fully understood from what I have read, but it does misfold and go prion like in PD. aS seems to be used in multiple processes and is found at synapses, maybe where it is affected by methamphetamines, but that is just a wild guess.

[Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). All diseases are determined by αS aggregate deposition but can be separated into distinct pathological phenotypes and diagnostic criteria. Here we attempt to reinterpret the literature, particularly in terms of how αS structure may relate to pathology.]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647174/
Note: ALL DISEASES ARE DETERMINED BY aS AGGREGATE DEPOSITION. PBT434 HAS SHOWN IT CAN INHIBIT aS AGGREGATION.

PD is progressive and irreversible:
There are two major features that identify PD: (1) progressive damage of dopaminergic neurons in the SNpc that leads to the depletion of dopamine (DA) release necessary to maintain essential functions (Mercuri and Bernardi, 2005), and (2) the appearance of non-motor symptoms associated to the degeneration of non-dopaminergic systems (Obeso et al., 2010) together with propagation and accumulation of Lewy bodies in different brain regions (Ross and Poirier, 2004; Desplats et al., 2009; Obeso et al., 2010) making PD an irreversible, and at the present, an incurable disorder (Singh et al., 2007).