Conclusions
This study shows for the first time the effects of PPS on human primary osteocytes isolated from the subchondral bone in patients with osteoarthritis of the knee. It is also the first demonstration of the production and secretion of NGF/proNGF by this cell type. PPS inhibited basal and TNFα-induced levels of proNGF secretion and TNFα induced NGF mRNA expression. PPS also inhibited TNFα-induced levels of the collagenase MMP-13. Together, this provides evidence that PPS may act at multiple levels to suppress the release of NGF and potentially other pain mediators in the subchondral bone, to ameliorate pain associated with knee osteoarthritis.
ConclusionsThis study shows for the first time the effects of...
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