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    It does appear that all treatments for DMD so far are problematic.
    Skipping does seem to be inferior to the theory of repair or replacement, or even partial replacement.
    Some interesting reading for those in lockdown with some spare time.
    One article from PPMD can explain and give easy-to-read insight into DMD Mutations.
    https://www.parentprojectmd.org/about-duchenne/what-is-duchenne/types-of-mutations/

    The next two articles are in relation to Exon Exchange and Repair approach, the first shorter notes, 154 you will note Voight is involved in, and the second article is more expanded detailed.

    Of interest also for those unfamiliar, you will see more about mdx mice, which are specific to DMD as they are a created mouse with DMD-like symptoms in use for DMD research.
    And these are the mice models we are using in our collaboration with Murdoch Childrens Research Institute in general investigation and also interestingly in combination with other DMD treatments.
    (154)
    https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)37595-5.pdf

    and expanded reading (10 years old )
    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010894

    It makes you wonder based on the results if Exon skipping is the most beneficial pathway.

    As i said, some general reading only if you're bored.
 
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