It does appear that all treatments for DMD so far are problematic.
Skipping does seem to be inferior to the theory of repair or replacement, or even partial replacement.
Some interesting reading for those in lockdown with some spare time.
One article from PPMD can explain and give easy-to-read insight into DMD Mutations.
https://www.parentprojectmd.org/about-duchenne/what-is-duchenne/types-of-mutations/
The next two articles are in relation to Exon Exchange and Repair approach, the first shorter notes, 154 you will note Voight is involved in, and the second article is more expanded detailed.
Of interest also for those unfamiliar, you will see more about mdx mice, which are specific to DMD as they are a created mouse with DMD-like symptoms in use for DMD research.
And these are the mice models we are using in our collaboration with Murdoch Childrens Research Institute in general investigation and also interestingly in combination with other DMD treatments.
(154)
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)37595-5.pdf
and expanded reading (10 years old )
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010894
It makes you wonder based on the results if Exon skipping is the most beneficial pathway.
As i said, some general reading only if you're bored.
- Forums
- ASX - By Stock
- PER
- Pfizer takeover of CD47 blocking Co.
Pfizer takeover of CD47 blocking Co., page-41
-
- There are more pages in this discussion • 1 more message in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
NEWS
Antler Copper Project hits major permitting milestone – air quality permit advances to final review
Add PER (ASX) to my watchlist
(20min delay)
|
|||||
Last
10.5¢ |
Change
0.000(0.00%) |
Mkt cap ! $94.66M |
Open | High | Low | Value | Volume |
10.5¢ | 10.5¢ | 9.8¢ | $58.09K | 574.8K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
1 | 38503 | 10.0¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
10.5¢ | 194063 | 5 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
1 | 100000 | 0.099 |
2 | 108491 | 0.098 |
1 | 30927 | 0.097 |
1 | 10004 | 0.096 |
3 | 162157 | 0.095 |
Price($) | Vol. | No. |
---|---|---|
0.105 | 194063 | 5 |
0.110 | 254663 | 3 |
0.115 | 1334300 | 6 |
0.120 | 381142 | 9 |
0.125 | 110429 | 2 |
Last trade - 16.10pm 04/10/2024 (20 minute delay) ? |
Featured News
PER (ASX) Chart |