Hi Captain Goodvybes,
In this order of drugs that increase autophagy.
1. An mTOR inhibitor with minimal side effects ala MPL
2. Metformin
3. Valproic acid.
The study below encapsulates autophagy and which drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412775/
Just for interest and expanding on autophagy this YouTube presentation gives a good simple understanding.
https://youtu.be/v5xBE1zvwUY?si=6fYgyaU2Nhve5XHC
Accelerated approval by the FDA seems probable due to biomarkers that PAA can clarify. But one may have to wait post 24 weeks P2/3 trial.
ODD next step up.
Kpax
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