Phase 3 DREAM HF-1 read-out, page-341

I would be very interested to know what the all cause mortality rate was in either groups.

According to data I've seen, 3 year survival for NYHA class 2 patients is roughly 70-80%.

As they measure at 30 months you would assume their survival in the control group would be towards the higher end of that range.

Now with say, a 25% mortality rate in a subgroup of 103 patients (206 with an assumed 50/50 control), that would be say 27 people died in the control group.

For a 60% reduction in mortality, that's roughly a difference of 10 people, right?

For a mortality difference of 10 patients in cohorts of 103 per arm I don't see how they got a significance of <0.037.

I haven't plugged it into an equation, but that seems like a very small difference in an N that isn't extremely large.

I know there are some stats experts in here, I'd love to be corrected.