I cant find the original story, but here is some info on...

I cant find the original story, but here is some info on Autophagy and the researcher who won the 2016 Nobel Prize. There is evidence that Nilotinib is a mTor inhibitor but they were looking mainly at Autophagy, and it's effects on Parkinsons and Alzheimer's.

According to the search results, there is evidence to suggest that Nilotinib, a tyrosine kinase inhibitor, can encourage autophagy. Autophagy is a cellular process involved in the degradation and recycling of cellular components, including proteins and organelles. Here are some key findings from the search results:- A clinical trial conducted at Georgetown University Medical Center found that Nilotinib appears to penetrate the blood-brain barrier and activate the process of autophagy in neurons, aiding in the clearance of accumulated beta-amyloid plaques and Tau tangles in Alzheimer's disease [[1]](https://gumc.georgetown.edu/news-release/nilotinib-appears-safe-and-affects-biomarkers-in-alzheimers-disease-clinical-trial/).- Another study mentioned that Nilotinib-induced autophagic changes increase endogenous parkin levels and ubiquitination, leading to amyloid clearance [[2]](https://pubmed.ncbi.nlm.nih.gov/24337465/) [[3]](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975659/). This suggests that Nilotinib can enhance autophagy and promote the clearance of toxic proteins associated with neurodegenerative diseases.- Additionally, a study on Parkinson's disease models demonstrated that Nilotinib can ameliorate autophagic clearance of alpha-synuclein, a protein implicated in Parkinson's disease, through autophagy activation [[4]](https://academic.oup.com/hmg/article/22/16/3315/627350).It's important to note that while these studies suggest a potential role for Nilotinib in promoting autophagy, further research is needed to fully understand the mechanisms and clinical implications. It is always recommended to consult with healthcare professionals or refer to reputable sources for the most up-to-date and accurate information on specific treatments and their effects on autophagy.

https://theconversation.com/nobel-prize-winning-autophagy-research-laid-groundwork-for-potNilotinibential-parkinsons-treatment-66474

https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd160867


A good read for a rainy day.


Cheers