EDUW 42 - PHILIPS - Monday 22 June, 17.00 - 18.00 PERFORMANCE STUDIES WITH THE CTNI HANDHELD POINT-OF CARE TEST V. Scharnhorst1 1 Catharina Hospital, 2 Technical University, Eindhoven, The Netherlands For point-of-care (POC) diagnostics to add value in the clinical setting analytical performance and integration in the clinical workflow are important. In this session we will present data on how the Philips Minicare system under development performs in these areas. Applications for this POC system are foreseen in the emergency department where time is of the essence. The first test under development on the Minicare system is a cardiac Troponin I (cTnI) assay with a turn-around time of less than 10 minutes. This assay has been used in a number of studies. The conditions under which POC tests are performed are typically less controlled compared to the central lab setting and there is usually little opportunity to perform any sample preparation........... Finally, after the test is completed quantitative results are presented on the screen of the instrument to enable rapid clinical decision making. The Minicare system offers connectivity to existing middleware systems already available in the hospital. Once incorporated in the hospital IT system the information is accessible for future reference, quality control and processing. Conclusions Several studies have been performed to assess the potential of the Minicare system under development to contribute to streamlining and improving laboratory services. The studies demonstrate the potential of the Philips Minicare cTnI assay to realize workflow improvements in the emergency department for patients with chest pain......
Conclusions- Several studies have been performed to assess the potential of the Minicare system under development to contribute to streamlining and improving laboratory services. The studies demonstrate the potential of the Philips Minicare cTnI assay to realize workflow improvements in the emergency department for patients with chest pain.
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Critical care, emergency medicine, blood gases, POCT M375 ANALYTICAL PERFORMANCE OF THE PHILIPS CTNI HANDHELD POINT-OF-CARE TEST V. Scharnhorst2 , M. Schoneveld1 , L. Van Lippen3 , F. De Theije3 , J. Nieuwenhuis3 1 Canisius- Wilhelmina Hospital 2 Laboratory, Catharina Hospital and Technmical University Eindhoven 3 Philips Handheld Diagnostics BACKGROUND-AIM Point-of-care (POC) diagnostics is very demanding in a number of areas: analytical performance, ease-of-use, and reliability. The Philips Minicare system utilizes an optomagnetic immunoassay technology based on nanoparticles that are magnetically actuated and optically detected in a stationary sample fluid. The actuation of nanoparticles by magnetic fields provides a high degree of control over each step of the assay, resulting in a low imprecision. The optical detection potentially yields sensitive and multiplexed assays in a cost-effective disposable cartridge. Applications are foreseen in the emergency department. The first test under development is a cardiac Troponin I (cTnI) assay with a turn-around time of less than 10 minutes. The sample-taking procedure is an important usability aspect. A convenient way to perform near-patient testing is to utilize capillary samples. In this study we investigate whether capillary samples could be used as an alternative sample type for cTnI testing. METHODS We collected and analyzed capillary and Li-heparin venous whole blood samples from 78 patients at the Cardiac Care Unit of two different hospitals covering a cTnI concentration range of up to 15,000 ng/l. 44/78 patients presented cTnI levels in the lower range....
RESULTS The correlation between the capillary and venous whole blood sample was very good. Over all patients (n=78), with cTnI values covering the full range of measurement, a correlation coefficient of R=0.998 and a slope of 1.05 (95%CI:1.03-1.07) were found. In the lower range of cTnI concentrations below 500 ng/l similar strong correlation was observed with a correlation coefficient of R=0.991 and a slope of 1.03 (95%CI:0.99-1.06). CONCLUSION The results obtained for the various sample types are very comparable and offer the potential to interchangeably use both capillary and venous samples. This supports near-patient testing in the workflow of patients suspected of Acute Coronary Syndrome arriving at the Emergency Department, enabling faster diagnosis or treatment.
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