https://www.sciencedirect.com/science/article/abs/pii/S0141813022028604
"tRNA-derived fragments (tRFs) are a class of regulatory non-coding RNAs that play essential biological functions in cancer and stress-induced diseases. Several lines of evidence suggest that 5′-tRF-GlyGCC participates in tumor progression; however, its molecular mechanisms remain unclear."
"5′-tRF-GlyGCC was found for the first time to bind directly to fat mass and obesity-associated proteins, and increase the activity of FTO demethylase, reducing eIF4G1 methylation, inhibiting autophagy, and promoting BC proliferation and metastasis."
If I'm interpreting this correctly, FTO isn't necessarily upregulated in this instance, 5′-tRF-GlyGCC is making FTO more effective. Target for CDX?
Pillar 1 - FTO (new thread), page-2359
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