Fig. 9. FTO inhibits DOX-induced ferroptosis by activating P53–P21/Nrf2 in a HuR-dependent m6A manner. Mechanistically, DOX-induced cardiotoxicity was associated with inhibition of FTO. FTO overexpression mediates m6A demethylation of P53, which is up-stream of P21. In addition, FTO also activateS P21/Nrf2 by mediating their mRNA m6A demethylation directly. P21/Nrf2 signaling is important for the anti-ferroptosis effect of FTO. HuR is crucial for FTO-mediated regulations of ferroptosis and P53–P21/Nrf2 by binding with their mRNAs and enhancing their stability. Moreover, P21 in turn, decreased the expression of HuR and P53 and HuR also up-regulated the expression of FTO, suggesting that there is a positive feedback loop for P53–P21.
- Forums
- ASX - By Stock
- RAC
- Pillar 1 - FTO (new thread)
Pillar 1 - FTO (new thread), page-2984
-
- There are more pages in this discussion • 12 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add RAC (ASX) to my watchlist
|
|||||
Last
$1.70 |
Change
0.050(3.03%) |
Mkt cap ! $289.6M |
Open | High | Low | Value | Volume |
$1.66 | $1.70 | $1.63 | $181.9K | 109.3K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
1 | 11946 | $1.70 |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
$1.75 | 27579 | 4 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
1 | 11946 | 1.700 |
1 | 6605 | 1.635 |
1 | 10752 | 1.615 |
2 | 20016 | 1.610 |
2 | 21000 | 1.600 |
Price($) | Vol. | No. |
---|---|---|
1.750 | 27579 | 4 |
1.755 | 990 | 1 |
1.760 | 500 | 1 |
1.800 | 824 | 2 |
1.820 | 4000 | 3 |
Last trade - 16.10pm 30/08/2024 (20 minute delay) ? |
Featured News
RAC (ASX) Chart |
The Watchlist
1CG
ONE CLICK GROUP LIMITED
Mark Waller, MD
Mark Waller
MD
Previous Video
Next Video
SPONSORED BY The Market Online