Pillar 1 - FTO (new thread), page-8

Crediting @IndexInvestor to some fishing around to the FTO link for Breast Cancer.

https://hotcopper.com.au/posts/49309223/single

Here's one article:

https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-019-1004-4

In summary, we provided compelling evidence that FTO, the key m6A demethylase, was up-regulated in human breast cancer. High expression level of FTO was significantly associated with poor clinical outcome in human breast patients. FTO dramatically promoted breast cancer cell proliferation, colony formation and metastasis through epigenetically down-regulating BNIP3. FTO demethylated m6A in the 3’UTR of BNIP3 and caused its degradation. BNIP3 acted as tumor sup- pressor and alleviated FTO-dependent tumor growth and metastasis. Altogether, our findings suggest that FTO may serve as a novel potential therapeutic target for breast cancer.

It also aligns with the original findings in the Cancer Cell paper.

https://www.researchgate.net/public...vasion/link/5f0ddeb592851c1eff0f7536/download


This is what RACE said about FTO in the preclinical study results for Breast Cancer.

https://cdn-api.markitdigital.com/a...access_token=83ff96335c2d45a094df02a206a39ff4