Pillar 1 - FTO

Thanks @wombat777 for creating the thread.

Looking at the above diagram, Is it fair to say that FTO inhibits Cancerous or tumorous cells in Breast Cancer, Leukaemia, Clear Cell Renal Cell Carcinoma, Bladder Cancer, Ovarian Cancer, Endometrial Cancer, Cervical Squamous Cell Carcinoma? At the same time, it also promotes the survival of individuals via colony formation, and programmed cell death that gets rid of abnormal or unwanted cells?

Having said that in the third diagram, isn't the FTO to cytotoxicity relationship, be orange colour or inhibit instead of promote? I am just trying to understand the diagrams in detail. Thanks.

I'm by no means a technical expert as I don't have a biological sciences background. I'm an engineer lol.

This is my understanding.
In some applications inhibiting FTO causes growth of cancer cells to be slowed.
In some applications inhibiting FTO causes cytotoxic agents to work better. Normal chemo agents are cytotoxic agents.

If you read the description for bladder cancer, I think it means that by blocking (or inhibiting) FTO activity cytotoxic agents can work better (cytotoxicity is promoted).

"and cisplatin-induced cytotoxicity of bladder cancer cells could be rescued by a highly selective inhibitor of FTO"
Cisplatin is used for bladder canner.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146684/