Breast Cancer Risk Factors You Cannot Change On this page A risk factor is anything that increases your chances of getting a disease, such as breast cancer. But having a risk factor, or even many, does not mean that you are sure to get the disease. Some risk factors for breast cancer are things you cannot change, such as getting older or inheriting certain gene changes. These make your risk of breast cancer higher. For information on other known and possible breast cancer risk factors, see: Lifestyle-related Breast Cancer Risk Factors Factors with Unclear Effects on Breast Cancer Risk Disproven or Controversial Breast Cancer Risk Factors Being born female This is the main risk factor for breast cancer. Men can get breast cancer, too, but this disease is much more common in women than in men. Getting older As you get older, your risk of breast cancer goes up. Most breast cancers are found in women age 55 and older. Inheriting certain gene changes About 5% to 10% of breast cancer cases are thought to be hereditary, meaning that they result directly from gene changes (mutations) passed on from a parent. BRCA1 and BRCA2: The most common cause of hereditary breast cancer is an inherited mutation in the BRCA1 or BRCA2 gene. In normal cells, these genes help make proteins that repair damaged DNA. Mutated versions of these genes can lead to abnormal cell growth, which can lead to cancer.
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