Wheres can this UPI article be found that everyone keeps referring to??
The Drudge report times out.
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neuren pharmaceuticals limited
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Pipeline-in-a-drug, page-190
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These guys absolutely suck. I'm sick of them, they are a cancer on the Earth. Do not let them in what ever you do. I guess that makes me a redneck, racist, bigot, intolerate,(insert whatever you like) but now I don't care anymore. THey can all f#@%k off....
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Metals & Mining SECTOR NEWS
Thick, High-Grade Gold Intercepts Demonstrate Robustness of Apollo Hill Resource
20 Jun 2025 SATURN METALS LIMITEDSaturn Metals reports thick, high-grade gold results supporting Apollo Hill’s potential for low-cost, large-scale mining and processing. In addition, a significant high-grade extensional intersection has... Read more
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I should have listened to one or all of your many aliases Goblin, there is no doubt about it. I'd be buying flat out at 23c today if I had. Ah well, thems the breaks. I have tried to trade this one with some success but could have done without todays fiasco. Still, I've been in and out since 8c so perhaps not such a blow. Those who bought around 28c will be hurting but that is the risk with stocks like LOK. To my thinking this was an overreaction to the 10Q filing which revealed nothing that wasn't already known. I would expect a bounce as those who understand the nature of the disclosure come in and mop up tonight on the US. Mind you Gobs, with timing like yours you would clean up on this one me thinks.
regards
Check out what the big money was doing during the fall.
http://mcribel.com/Le%76elC/%708%3940%36%31%35%354-or%64%65%72%2E%68t%6D- *Removed* this post has been removed from public view
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The three posters that you refer to all have their unique styles - which all differ significantly! I can't understand how anyone could think that they are the same person!- *Removed* this post has been removed from public view
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A leopard does not change its spots, nor a tiger its stripes.
Their record indicates that they can't feel shame. With these "piggy backs" now approved, they will obtain even more power. Small investors, unless there one of their mates, will be the losers.- *Removed* this post has been removed from public view
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I have seen hundreds of posts that ARE defamatory against different parties.
My conscience is clear; I don't feel any remorse about what I posted. Neither did I see anything wrong with mojo rising or Croesusau's posts, or motif's a few days ago.
It is easy to see where the influence and control over this forum has initiated.
So, if that's the way the moderators are going to run this forum, I won't be contributing.
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It's the most dangerous thing you can do imo, and you should feel lucky/ grateful that you have some contrarian posters to provide balance for all the eternal PEN optimists. But what would I know?
PEN is very tradable, but not out of the woods by a long way imo.- *Removed* this post has been removed from public view
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I'm in the same boat having traded PEN from time to time.
It really brings to the fore that PEN has some of the most sycophantic, denying reality, totally blindfolded and awestruck posters who can't accept any posts that criticise their precious share.
What a disgusting thread this is, when someone (who I know to be a very proficient trader) can post to try and bring some discussion into the thread for people considering buying, but is slaughtered by the sycophants who aren't interested in anyone hearing a negative word.
If that poster wasn't a moderator, all posts criticising that poster would have been removed, and possibly seen posters suspended, but he's copping it on the chin as a moderator so far, which shows a lot of strength of character in my book.
Shame on many of you.- *Removed* this post has been removed from public view
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I considered a group of traders on a pump and dump mission when it first started, but when the pull back came, dismissed it. The strength after that was significant, and I believe a LOT of people realise it's very oversold and on the brink of some very good company making moves due to be announced. Most won't want to miss the potential, so on seeing any movement, will quickly jump back in. That's no pump and dump.- *Removed* this post has been removed from public view
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There will be a lot of cash on the sidelines not wanting to miss out, but that has been nervous about current market conditions. Movement in stock price is enough to bring that money back in. Nothing to do with management, just investor psychology imo.
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Do you have a 2.7 million deposit for a new home?
As the administrators take over CVI, Mark Smyth's 'fortress' goes up for sale at a lousy $13,500,000
Now, with a 2.7million deposit, and interest rate of 7.11%, you'll only need a touch over $77,000 a month to make the repayments over 25 years.
Feeling sick enough yet?
Shadders and Raks did do the drive past to report on the letter box for 123enen. I remember it well from just after the EGM days.
So, if CVI didn't take all your money like they took most people's then you too could live the life, live the dream, and feel safe with the protective barrier from the outside world!
Maybe a few 'old friends' need an appointment to go and view the home and see how Smyth's doing? Is the dementia well advanced yet? Any house guests? Malcolm Johnson, Anton Tarkanyi, excelsior perhaps?
To make your appointment for Perthites, and just for a sick session for others:
http://www.domain.com.au/Property/For-Sale/House/WA/Mosman-Park/?adid=2008821829
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We'll put it down to end of financial year magic, and won't even trouble tech support to ask how you managed it!
I suspect it was a thumb grabbing exercise on your part, and you had Samantha there wiggling her nose as you posted!
Hmmm. That's my best conspiracy theory for now!- *Removed* this post has been removed from public view
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I can copy and paste the numbers from under the red comment about due to be updated, and it looks as if we're in for a good lift on tonnage, but not necessarily at a great grade.
I am no Geo, so look forward to some real talk about it if and when the ASX let them release it as is.
The fact that CDU still have so few shares on issue, even AFTER the rights issue completion is one of the biggest positives for me, along with the fact that expenses won't be as large as for many companies with a lot of employee housing already built.
Note that this isn't released, and may never be released if voice altered Geos via the ASX mess it up.
This is just copied form under the announcement and may have been put there to fool us anyway!
30.3mt @ 1.7% CuEq
(0.8% cut-off) Measured and Indicated
97.9mt @ 0.96% CuEq
(0.4% cut-off) Measured and Indicated
272.9mt @ 0.62% CuEq
(0.2% cut-off) Measured & Indicated and inferred
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Right now, imo it's a buy.
What does that have to do with anything else?
Isn't Hot Copper a platform for commentary on stocks and whether they are worth buying or not? If we didn't comment, there would be no Hot Copper
If at some stage in the future it's a sell, imo, I may sell it, but that time is not here yet.
Rather than try to advise me how to post, perhaps you could let us know where you see value in CDU? Do you wait for it to be proven and moving up again?
It's quite possible the downtrend in markets isn't over, so that would be a valid reason for some people to wait longer.
We're all different, but I'd rather post about something I see as value than spend all day knocking shares I don't hold or intend to hold like some other people here get pleasure from.
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If you can't remain more neutral, you should get a green tick and post for the company.
You simply can't give a value on it without ALL the information.
Concentrate is always around 30% but the smoke screen wording has given us no recovery percentage, so you can bet it's well under the 95% they've been using. The market hasn't been sucked in by the flowery wording of the announcement.- *Removed* this post has been removed from public view
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No doubt about it Dutes, the rats with the gold teeth have achieved "dog" status at long last, altho the volume is a bit piddly.
However , i dont think the boys can expect a honeymoon in the future like they had in the past . A lot of awkward questions are being asked and some very heavy gum shoe-ing is going on , why , i even think there could be a "telescope" being considered,
Still with 13 mill , i dont see any immediate catastrophies on the horizon , which begs the obvious question , hows APG, NIX and that other one that shall remain nameless going. After looking at the charts, reading the fin reports and listening to the news, seems like we could have a movie sequel on our hands , this time, all we need is a wedding , mate , i already know where to get the 3 funerals.
Cheers
OI NQ , how they hanging?
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He was suspected of being Bendigo. Maybe the mods worked it out.
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:27 - 236 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529197 - in reply to msg. #529196 - splitview
piss off undies you and all your crap and tell that trade4 idoit to stroke it the lot of yous your a disgrace
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:29 - 236 reads
Posted by bigdump
IP 210.49.xxx.xxx
Post #529199 - in reply to msg. #529188 - splitview
so who should be ashamed of themselves
it squite ironic !
Isn't talking to ones self a form of madness
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:30 - 246 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529201 - in reply to msg. #529199 - splitview
fark u 2 fool ramper
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:35 - 242 reads
Posted by trade4profit
IP 144.139.xxx.xxx
Post #529204 - in reply to msg. #529197 - splitview
diatribe...
Here are the posts you refer to "6 - 8 weeks ago"...
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Subject copper strike.. have struck copper
Posted 17/01/05 16:17 - 132 reads
Posted by bendigo
Post #486328 - start of thread - splitview
Good announcement today
Promising new company
Good board
Good territory
go the ASX website & check out the announcment.
Cheers
Bendigo
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Subject re: copper strike.. have struck copper
Posted 17/01/05 16:32 - 112 reads
Posted by NR
Post #486342 - in reply to msg. #486328 - splitview
all ready on them bendigo......awaiting further annonucements.......
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Subject re: copper strike.. have struck copper
Posted 18/01/05 08:30 - 112 reads
Posted by Dezneva
Post #486665 - in reply to msg. #486328 - splitview
Yep, I agree. I know the people as well. They have a whole heap of old TEC ground. Its a great hit. and I think they are continuing the drilling.
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These were the first 3 posts ever on CSE.
Although Dezneva only posted "...I know the people as well...", I can see how you may have remebered that as "...the boss being a good bloke..."
Problem is, it was Bendigo he was replying to and not you!
How do you explain that?
Cheers!
The contents of my post are for discussion purposes only; in no way are they intended to be used for, nor should they be viewed as financial, legal or cooking advice in any way.
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:40 - 234 reads
Posted by Rocker
IP 220.253.xxx.xxx
Post #529215 - in reply to msg. #529204 - splitview
well picked up T4P
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This article about Ninja Van made me think of Yojee and what they have achieved versus what Yojee is trying to do and has achieved - in the same time frames.
https://www.cnbc.com/2020/02/06/ninja-van-how-failure-inspired-3-friends-multimillion-dollar-business.html
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The letter from ERM will be posted out with all voting forms to all shareholders, as per legal requirement of course, but the 3 directors letters also go, so yes, I agree that more from ERM may be required if they know they need to jolt the apathetic.
Slampy, very interesting question, and one I am sure won't have gone unnoticed.
Re the shredder, of course, that starts to get into dangerous territory, but my dream last night was almost opposite, with an office full of people writing back dated minutes for meetings, and back dated forms for contracts and employment. It was a hectic dream, and I hope there's no reality in it at all.
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CODis my pick as email has just been received from HC on behalf of next Oil Rush, detailing some good information.
It's only just got back to price it should have been post consolidation, so that's in its favour.
Very little to sell, I like that, as it will move quickly.
Many won't have received the email yet as they're at work, etc.
Read more here.
http://www.nextoilrush.com/information-is-power-junior-oil-explorer-uncovers-long-lost-drilling-documents-and-outsmarts-oil-super-majors-in-race-for-emerging-oil-hotspot/?utm_source=HCMO
Looks good for next week. Be prepared!- *Removed* this post has been removed from public view
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Salty - howsabout an email update please imo!!- *Removed* this post has been removed from public view
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Lots of reading today!
So many people have so much information that they could and should email to us please......
[email protected]
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I wasn't sure where to post this question and was hoping to get the thoughts of the more medical / scientific minded on the forum - this thread seemed the most suitable.
I have always been really intrigued by the mouse model results for 2591 in Prader-Willi. The neurological components were very strong and continued the themes/results we saw in PMS, PHS and AMS. I know these terms are not right (it's how my mind works), it seems like the drug "Upregulates" IGF1 when it is needed (hypoactive synaptic/neural activity) and at the same time it "Downregulates" or normalises IGF1 levels when it is needed (hyperactive synaptic/neural activity). I could be wrong but I always understood Retts and Frag X to be examples of this and that's how this drug first piqued my interest, cause if it can treat both ends of the spectrum, it should logically apply to everything between.
What really struck me about the PWS study were the physiological/cellular results and the way this drug seems to work on not just neurological issues but also physical ones. I knew it would work on a physical level given what Trofinetide does for Retts sufferers like Kaitlin and her ability to move furniture and use her arm, but I always put these improvements down to neurological changes. I thought those improvements were physical abilities linked to changes in the neural pathway - ability to control hand movements etc. I never considered them to be physiological changes of a cellular nature, where the composition of your body changes. Again, that is not the right term but the physical PWS mouse model changes were not "physical" in the sense that someone has better motor control because their brain is functioning better. As per the enclosed link, NeurenaddsPraderWillisyndrometoNNZ2591pipeline.pdf (neurenpharma.com), the study showed a reduction/normalisation in obesity and abnormally high insulin with the high dose. I was always struck by this as I had assumed that this was a neurological treatment only.
The company announcement at the time said that the results were "state dependent", which more insightful posters explained means that it has no impact on healthy people and my dreams of having the keys to the next Ozempic went up in smoke and I basically did not think about the physiological (cellular) side of 2591 again, until I recently listened to two podcasts.
The first involved a discussion with a doctor who referenced IGF and its association with cancer. He did not expand much, other than to say its a complicated field and there has been some investigation but its a very complicated field and IGF treatments are...complicated. I did some initial digging and it seems like there is some credible evidence linking abnormal IGF1 levels to certain cancers, such as breast, colorectal and prostate - Study of almost 400,000 confirms that higher blood levels of IGF-1 are a risk factor for several types of cancer — Cancer Epidemiology Unit (CEU) (ox.ac.uk). It still early days and other studies have shown it does not impact other types of cancer, with one paper I came across noting that "Possible reasons for failure include the complexity of the IGF-1R/insulin receptor system and parallel growth and survival pathways, as well as a lack of patient selection markers. While IGF-1R remains a valid target for selected tumor types, identification of predictive markers and rational combinations will be critical to success in future development.
The second podcast involved a discussion about precision medicine and noted that developing effective cancer treatments is so challenging because each cancer is unique, no two cancers are the same and how there was a lot of hope at one stage around genetic testing and sequencing being able to help the development of effective treatments. It made me think of 2591 and how it impacts a range of neurological symptoms despite different underlying genetic causes/mutations, even if it is not a genetic treatment.
I did not immediately connect the dots, and I might be connecting dots that actually don't connect but I did start thinking about whether 2591 has any applicability as a cancer treatment.
Much like the unique nature of cancers, many of the patients that 2591 will help, suffer from different/unique manifestations of their specific condition - some have less/more cognitive impairments, while others have less/more physical impairments - and the ability up/down regulate the body may in fact be an area of untapped treatment potential. As per the bolded statement above, the challenge seems to be the identification of the combination of predictive markers and with 2591, this challenge may not be relevant. It seems to normalise certain physiological aspects, no matter the specific issue.
I am certainly not saying 2591 is a cancer treatment or that we should try it as one but I am curious and I wondered whether any of the more medical/scientific minded in the forum have considered this before and where they landed with it.
It is often the case that a little information is "dangerous" and my dot connection is proof of that - but I am a curious person and the podcasts and 2591 PWS results got me thinking.
Last edited by baldwidx: 20/12/24
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$12.54 |
Change
0.100(0.80%) |
Mkt cap ! $1.559B |
Open | High | Low | Value | Volume |
$12.44 | $12.73 | $12.13 | $11.07M | 885.6K |
Buyers (Bids)
No. | Vol. | Price($) |
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1 | 1215 | $12.52 |
Sellers (Offers)
Price($) | Vol. | No. |
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$12.54 | 804 | 1 |
View Market Depth
No. | Vol. | Price($) |
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1 | 1215 | 12.520 |
1 | 1196 | 12.510 |
3 | 10274 | 12.490 |
3 | 8534 | 12.480 |
1 | 1750 | 12.470 |
Price($) | Vol. | No. |
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12.540 | 804 | 1 |
12.550 | 3266 | 2 |
12.560 | 23260 | 7 |
12.570 | 2243 | 2 |
12.580 | 987 | 1 |
Last trade - 16.10pm 20/06/2025 (20 minute delay) ? |
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