PNV Media Thread, page-1082

And another, I don't know if there will lead to anything useful, maybe others like HT may have a better understanding of these?

https://www.researchgate.net/public...ydrogel_scaffolds_for_soft-tissue_engineering


Article
Epoxy-amine synthesised hydrogel scaffolds for soft-tissue engineering

• September 2010
• Biomaterials 31(25):6454-67

DOI: 10.1016/j.biomaterials.2010.05.008

• Source
• PubMed

Authors:

Zuratul Abdul Hamid

• University of Melbourne

Anton Blencowe

• University of South Australia

Berkay Ozcelik

• PolyNovo Limited

Jason Palmer

• Saint Vincent's Institute

Show all 9 authors




To read the full-text of this research, you can request a copy directly from the authors.
Citations (44)
References (70)


Abstract
Highly porous and biodegradable hydrogels based on poly(ethylene glycol) (PEG) and cystamine (Cys) were fabricated using epoxy-amine chemistry and investigated as scaffolds for soft-tissue engineering. Whereas the application of fused-salt templates provided a comprehensive interconnecting pore morphology, the incorporation of a specially designed poly(epsilon-caprolactone) (PCL) cross-linker provided enhanced mechanical function without adversely effecting the scaffolds positive biological interactions. The addition of only 1.2 wt% of the PCL cross-linker was sufficient to provide improvements in the ultimate stress of 30-40%. In vitro studies not only confirmed the non-cytotoxic nature of the scaffolds, but also their degradation products, which were isolated and characterised by nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionisation time-of-flight mass spectroscopy (MALDI ToF MS). In vivo trials were conducted over a period of 8 weeks through implantation of the scaffolds into the dorsal region of rats. At both 2 and 8 week time points the explants revealed complete infiltration by the surrounding tissue and the development of a vascular network to support the newly generated tissue, without an excessive foreign-body response.

https://core.ac.uk/download/pdf/158169512.pdf