The study group of Prana in Melbourne has been great, but only in neurodegeneration. Now with Dr. Sinclair, it gets much bigger and these new researchers cover a much bigger area what is also indicated in the new name, Alterity Therapeutics. To get some understanding who these new people round Dr. Sinclair are I post here list of authors in his last papers. It is however clear that these people do not work for Prana and to call them collaborators is not right. However, these people are friends of Dr. Sinclair and he works with them. IMO it is good also to Alterity Therapeutics.

Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008.

Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A¹, Huang GX², Bonkowski MS³, Longchamp A⁴, Li C⁵, Schultz MB³, Kim LJ⁵, Osborne B⁶, Joshi S⁶, Lu Y³, Treviño-Villarreal JH⁴, Kang MJ⁵, Hung TT⁷, Lee B⁷, Williams EO⁸, Igarashi M⁸, Mitchell JR⁴, Wu LE⁵, Turner N⁶, Arany Z⁹, Guarente L¹⁰, Sinclair DA¹¹.

Author information

1

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia; Paul F. Glenn Center for Science of Aging Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Bldg. 421, Philadelphia, PA 19104, USA.

3

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

4

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

5

Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

6

Mitochondrial Bioenergetics Laboratory, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.

7

Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW 2052, Australia.

8

Paul F. Glenn Center for Science of Aging Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

9

Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Bldg. 421, Philadelphia, PA 19104, USA. Electronic address: [email protected].

10

Paul F. Glenn Center for Science of Aging Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: [email protected].

11

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: [email protected].

Abstract

A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1-SIRT7) that mediate the benefits of exercise and dietary restriction (DR). We show that SIRT1 in endothelial cells is a key mediator of pro-angiogenic signals secreted from myocytes. Treatment of mice with the NAD⁺ booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H₂S), a DR mimetic and regulator of endothelial NAD⁺ levels. These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the

Here is the list of authors in the telomere paper:

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Cell Metab. 2019 Mar 20. pii: S1550-4131(19)30129-9. doi: 10.1016/j.cmet.2019.03.001. [Epub ahead of print]

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Amano H¹, Chaudhury A², Rodriguez-Aguayo C³, Lu L⁴, Akhanov V⁵, Catic A⁵, Popov YV⁶, Verdin E⁷, Johnson H⁸, Stossi F⁸, Sinclair DA⁹, Nakamaru-Ogiso E¹⁰, Lopez-Berestein G³, Chang JT¹¹, Neilson JR², Meeker A¹², Finegold M¹³, Baur JA¹⁴, Sahin E¹⁵.

Author information

1

Department of Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

2

Department of Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

3

Department of Experimental Therapeutics & Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4

Oncology Informatics & Genomics, Phillips Healthcare, Cambridge, MA 02141, USA.

5

Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

6

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

7

Gladstone Institute of Virology and Immunology, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Buck Institute for Research on Aging, Novato, CA, USA.

8

Department of Molecular and Cellular Biology & Integrated Microscopy Core, Baylor College of Medicine, Boston, MA, USA.

9

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

10

Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

11

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

12

Department of Pathology, Department of Oncology, Johns Hopkins Medical Institution, Baltimore, MD 21231, USA.

13

Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA.

14

Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA.

15

Department of Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: [email protected].