Well, these patients are at end of their treatment journey; other options have been exhausted. From the inclusion criteria here: https://clinicaltrials.gov/ct2/show/NCT04876651
Should have received one line of prior taxane therapy or have refused or be ineligible for taxanes
Once a patient stops responding to Cabazitaxel there is no point continuing it. And it's rarely curative.
Also, side effects from chemo are horrible. Really terrible. So you wouldn't want any adverse events from chemo being ascribed to TLX591.
Problem with ProstACT Clinical Trial, page-4
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