Hi Alois, Merry Christmas
He was talking about the end of late stage 2-3yr trials which cant be compared with initial evidence from a 12 week trial.
You may enjoy this link. It looks to me that Mark Smith has been a stand alone effort against the amyloid theory.
http://blogs.forbes.com/robertlangreth/2010/08/23/renegade-researcher-says-alzheimers-drugs-from-bristol-myers-pfizer-may-be-unsafe-or-ineffective/
The two comments after the article are interesting.
He also co wrote the post to the alzforum which concluded with:
"When seen together with the antioxidant role of A? through copper chelation (Hayashi et al., 2007), the reparative power of the amyloid pathway cannot be questioned "(Rottkamp et al., 2001; Castellani et al., 2009).
It looks like he was in full agreement with the conclusions from Prana's Cell publication.
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