Thanks for the references @hottod - this recent review by Guan is also quite good (Neuren even gets a mention!), section 3 in particular is a good summary of the mode of action of cGP.
https://www.mdpi.com/1420-3049/28/3/1021
I think the subtlety here is that cGP can indeed up and down regulate IGF-1 activity as part of normal homeostasis, but it is dependent on the molar ratio of cGP/IGF-1 –
“The different effects of cGP on endothelial cell survival/growth are dependent on its concentration relative to that of IGF-1, in which a higher cGP/IGF-1 molar ratio leads to a stimulatory effect, whereas a lower cGP/IGF-1 ratio results in an inhibitory effect.”
This is mediated by competitive binding of cGP and IGF-1 to the IGF binding protein IGFBP-3 as shown in the summary diagram from one of Jon’s slides
Given that a low cGP ratio is required to obtain an inhibitory effect, Guan concludes
“In general, the clinical relevance of cGP is in those conditions associated with IGF-1 deficiency…”
So my interpretation remains that NNZ-2591 is unlikely to be useful in CNS indications where the aim is to reduce IGF-1 activity but, tbh, endocrinology is not really my area so happy to stand corrected!
Finally, I note that although IGF-1 levels are elevated in both MDD and schizophrenia, this is not necessarily seen as a negative but rather a response to the diseases. It is questionable, however, whether NNZ-2591 would provide any significant additional benefit as the disease pathophysiology is quite different to neurodevelopmental disorders.
- Forums
- ASX - By Stock
- Psychiatric Indications
Thanks for the references @hottod - this recent review by Guan...
-
- There are more pages in this discussion • 4 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add NEU (ASX) to my watchlist
|
|||||
Last
$13.48 |
Change
0.150(1.13%) |
Mkt cap ! $1.717B |
Open | High | Low | Value | Volume |
$13.49 | $13.56 | $13.30 | $1.526M | 113.5K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
21 | 995 | $13.46 |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
$13.48 | 726 | 18 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
21 | 995 | 13.460 |
5 | 382 | 13.450 |
16 | 1073 | 13.440 |
6 | 1702 | 13.430 |
10 | 754 | 13.420 |
Price($) | Vol. | No. |
---|---|---|
13.480 | 721 | 18 |
13.490 | 630 | 8 |
13.500 | 1591 | 6 |
13.510 | 255 | 2 |
13.520 | 715 | 3 |
Last trade - 12.08pm 12/09/2024 (20 minute delay) ? |
Featured News
NEU (ASX) Chart |