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Lots of love for midkine in the kidney disease context...

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mightypirate

551 Posts.

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29/09/17

11:19

Post #: 27545712
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Lots of love for midkine in the kidney disease context (biomarker and therapeutic target).

Urine and serum midkine levels in an Australian chronic kidney disease clinic population: an observational study

http://bmjopen.bmj.com/content/7/9/e014615

Published in print 1 September 2017.

Published online 27 September 2017.

Conclusion
This is the first study to analyse MK levels in a CKD population and reveals that serum and urine MK levels become higher with increasing CKD stage, more than 10-fold by CKD 5. The source of these high levels is at least in part related to clearance, although there is also support for increased renal tubular production in the CKD setting. The impact of chronic systemic exposure to these supraphysiological levels is yet to be established, but increasing animal data suggest this may be systemically significant, and the relationship with RAS blockade and proteinuria supports the possibility of MK being a driver in the final converging pathological stages of CKD. More research is required to explore MK’s role in the progression and systemic consequences of CKD and its potential as a biomarker and therapeutic target.

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CDY Price at posting: 2.5¢ Sentiment: Buy Disclosure: Held
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