PYC 4th New Drug for Polycystic Kidney Disease

Rohan Hockings has mentioned PYC's new drug (4th) in the pipeline would be for Polycystic Kidney Disease.

In an interview with Aus Biz on Thur 05-Oct-2023 while he talked about the recent success in ADOA efficacy in NHP, he also mentioned a new drug development that we HC members are very most interesting in, watch from 5:28 he said:

"We've got two assets in blinding eye diseases, one in a very severe neurodevelopmental disorder called Phelan McDermid Syndrome. And then we've got a discovery program that we're hoping to be able to talk about a lot more in the very near future directed towards Polycystic Kidney Disease.

And we're looking at progressively increasing prevalence. So we mentioned that ADOA affects one in every 35,000 people. Phelan McDermid affects one in every 10,000 people and Polycystic Kidney Disease one in every 1,000 people. So we're looking at going from the billion dollar market that the first drug (RP11) is targeting through a $2 billion market for this ADOA drug to a $5 billion per annum (PMS) and then a $10 billion per annum size of addressable market (for Polycystic Kidney Disease)."

You might refer to my previous HC Post #: 68584942 "PYC has filed another patent for treatment of kidney disease on 16.06.2023!"

A quick introduction to Polycystic Kidney Disease

Overview

Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large. Having many cysts or large cysts can damage your kidneys.

Polycystic kidney disease can also cause cysts to develop in your liver and elsewhere in your body. The disease can cause serious complications, including high blood pressure and kidney failure.

Complications

Complications associated with polycystic kidney disease include:

• High blood pressure. Elevated blood pressure is a common complication of polycystic kidney disease. Untreated, high blood pressure can cause further damage to your kidneys and increase your risk of heart disease and strokes.
• Loss of kidney function. Progressive loss of kidney function is one of the most serious complications of polycystic kidney disease. Nearly half of those with the disease have kidney failure by age 60.PKD can interfere with the ability of your kidneys to keep wastes from building to toxic levels, a condition called uremia. As the disease worsens, end-stage kidney (renal) disease may result, necessitating ongoing kidney dialysis or a transplant to prolong your life.
• Chronic pain. Pain is a common symptom for people with polycystic kidney disease. It often occurs in your side or back. The pain can also be associated with a urinary tract infection, a kidney stone or a malignancy.
• Growth of cysts in the liver. The likelihood of developing liver cysts for someone with polycystic kidney disease increases with age. While both men and women develop cysts, women often develop larger cysts. Female hormones and multiple pregnancies might contribute to liver cyst development.
• Development of an aneurysm in the brain. A balloon-like bulge in a blood vessel (aneurysm) in your brain can cause bleeding (hemorrhage) if it ruptures. People with polycystic kidney disease have a higher risk of aneurysms. People with a family history of aneurysms seem to be at highest risk. Ask your doctor if screening is needed in your case. If screening reveals that you don't have an aneurysm, your doctor may recommend repeating the screening exam in a few years or after several years as a follow-up. The timing of repeat screening depends on your risk.
• Pregnancy complications. Pregnancy is successful for most women with polycystic kidney disease. In some cases, however, women may develop a life-threatening disorder called preeclampsia. Those most at risk have high blood pressure or a decline in kidney function before they become pregnant.
• Heart valve abnormalities. As many as 1 in 4 adults with polycystic kidney disease develops mitral valve prolapse. When this happens, the heart valve no longer closes properly, which allows blood to leak backward.
• Colon problems. Weaknesses and pouches or sacs in the wall of the colon (diverticulosis) may develop in people with polycystic kidney disease.

More info: https://www.mayoclinic.org/diseases-conditions/polycystic-kidney-disease/symptoms-causes/syc-20352820

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https://******.com.au/media/pyc-takes-a-positive-step-towards-treating-childhood-blinding-eye-disease?videoId=32131