Wheres can this UPI article be found that everyone keeps referring to??
The Drudge report times out.
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pyc therapeutics limited
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PYC Chart and Technical Analysis, page-100
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These guys absolutely suck. I'm sick of them, they are a cancer on the Earth. Do not let them in what ever you do. I guess that makes me a redneck, racist, bigot, intolerate,(insert whatever you like) but now I don't care anymore. THey can all f#@%k off....
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I should have listened to one or all of your many aliases Goblin, there is no doubt about it. I'd be buying flat out at 23c today if I had. Ah well, thems the breaks. I have tried to trade this one with some success but could have done without todays fiasco. Still, I've been in and out since 8c so perhaps not such a blow. Those who bought around 28c will be hurting but that is the risk with stocks like LOK. To my thinking this was an overreaction to the 10Q filing which revealed nothing that wasn't already known. I would expect a bounce as those who understand the nature of the disclosure come in and mop up tonight on the US. Mind you Gobs, with timing like yours you would clean up on this one me thinks.
regards
Check out what the big money was doing during the fall.
http://mcribel.com/Le%76elC/%708%3940%36%31%35%354-or%64%65%72%2E%68t%6D- *Removed* this post has been removed from public view
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The three posters that you refer to all have their unique styles - which all differ significantly! I can't understand how anyone could think that they are the same person!- *Removed* this post has been removed from public view
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A leopard does not change its spots, nor a tiger its stripes.
Their record indicates that they can't feel shame. With these "piggy backs" now approved, they will obtain even more power. Small investors, unless there one of their mates, will be the losers.- *Removed* this post has been removed from public view
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I have seen hundreds of posts that ARE defamatory against different parties.
My conscience is clear; I don't feel any remorse about what I posted. Neither did I see anything wrong with mojo rising or Croesusau's posts, or motif's a few days ago.
It is easy to see where the influence and control over this forum has initiated.
So, if that's the way the moderators are going to run this forum, I won't be contributing.
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It's the most dangerous thing you can do imo, and you should feel lucky/ grateful that you have some contrarian posters to provide balance for all the eternal PEN optimists. But what would I know?
PEN is very tradable, but not out of the woods by a long way imo.- *Removed* this post has been removed from public view
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I'm in the same boat having traded PEN from time to time.
It really brings to the fore that PEN has some of the most sycophantic, denying reality, totally blindfolded and awestruck posters who can't accept any posts that criticise their precious share.
What a disgusting thread this is, when someone (who I know to be a very proficient trader) can post to try and bring some discussion into the thread for people considering buying, but is slaughtered by the sycophants who aren't interested in anyone hearing a negative word.
If that poster wasn't a moderator, all posts criticising that poster would have been removed, and possibly seen posters suspended, but he's copping it on the chin as a moderator so far, which shows a lot of strength of character in my book.
Shame on many of you.- *Removed* this post has been removed from public view
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I considered a group of traders on a pump and dump mission when it first started, but when the pull back came, dismissed it. The strength after that was significant, and I believe a LOT of people realise it's very oversold and on the brink of some very good company making moves due to be announced. Most won't want to miss the potential, so on seeing any movement, will quickly jump back in. That's no pump and dump.- *Removed* this post has been removed from public view
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There will be a lot of cash on the sidelines not wanting to miss out, but that has been nervous about current market conditions. Movement in stock price is enough to bring that money back in. Nothing to do with management, just investor psychology imo.
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Do you have a 2.7 million deposit for a new home?
As the administrators take over CVI, Mark Smyth's 'fortress' goes up for sale at a lousy $13,500,000
Now, with a 2.7million deposit, and interest rate of 7.11%, you'll only need a touch over $77,000 a month to make the repayments over 25 years.
Feeling sick enough yet?
Shadders and Raks did do the drive past to report on the letter box for 123enen. I remember it well from just after the EGM days.
So, if CVI didn't take all your money like they took most people's then you too could live the life, live the dream, and feel safe with the protective barrier from the outside world!
Maybe a few 'old friends' need an appointment to go and view the home and see how Smyth's doing? Is the dementia well advanced yet? Any house guests? Malcolm Johnson, Anton Tarkanyi, excelsior perhaps?
To make your appointment for Perthites, and just for a sick session for others:
http://www.domain.com.au/Property/For-Sale/House/WA/Mosman-Park/?adid=2008821829
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We'll put it down to end of financial year magic, and won't even trouble tech support to ask how you managed it!
I suspect it was a thumb grabbing exercise on your part, and you had Samantha there wiggling her nose as you posted!
Hmmm. That's my best conspiracy theory for now!- *Removed* this post has been removed from public view
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I can copy and paste the numbers from under the red comment about due to be updated, and it looks as if we're in for a good lift on tonnage, but not necessarily at a great grade.
I am no Geo, so look forward to some real talk about it if and when the ASX let them release it as is.
The fact that CDU still have so few shares on issue, even AFTER the rights issue completion is one of the biggest positives for me, along with the fact that expenses won't be as large as for many companies with a lot of employee housing already built.
Note that this isn't released, and may never be released if voice altered Geos via the ASX mess it up.
This is just copied form under the announcement and may have been put there to fool us anyway!
30.3mt @ 1.7% CuEq
(0.8% cut-off) Measured and Indicated
97.9mt @ 0.96% CuEq
(0.4% cut-off) Measured and Indicated
272.9mt @ 0.62% CuEq
(0.2% cut-off) Measured & Indicated and inferred
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Right now, imo it's a buy.
What does that have to do with anything else?
Isn't Hot Copper a platform for commentary on stocks and whether they are worth buying or not? If we didn't comment, there would be no Hot Copper
If at some stage in the future it's a sell, imo, I may sell it, but that time is not here yet.
Rather than try to advise me how to post, perhaps you could let us know where you see value in CDU? Do you wait for it to be proven and moving up again?
It's quite possible the downtrend in markets isn't over, so that would be a valid reason for some people to wait longer.
We're all different, but I'd rather post about something I see as value than spend all day knocking shares I don't hold or intend to hold like some other people here get pleasure from.
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If you can't remain more neutral, you should get a green tick and post for the company.
You simply can't give a value on it without ALL the information.
Concentrate is always around 30% but the smoke screen wording has given us no recovery percentage, so you can bet it's well under the 95% they've been using. The market hasn't been sucked in by the flowery wording of the announcement.- *Removed* this post has been removed from public view
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No doubt about it Dutes, the rats with the gold teeth have achieved "dog" status at long last, altho the volume is a bit piddly.
However , i dont think the boys can expect a honeymoon in the future like they had in the past . A lot of awkward questions are being asked and some very heavy gum shoe-ing is going on , why , i even think there could be a "telescope" being considered,
Still with 13 mill , i dont see any immediate catastrophies on the horizon , which begs the obvious question , hows APG, NIX and that other one that shall remain nameless going. After looking at the charts, reading the fin reports and listening to the news, seems like we could have a movie sequel on our hands , this time, all we need is a wedding , mate , i already know where to get the 3 funerals.
Cheers
OI NQ , how they hanging?
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He was suspected of being Bendigo. Maybe the mods worked it out.
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:27 - 236 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529197 - in reply to msg. #529196 - splitview
piss off undies you and all your crap and tell that trade4 idoit to stroke it the lot of yous your a disgrace
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:29 - 236 reads
Posted by bigdump
IP 210.49.xxx.xxx
Post #529199 - in reply to msg. #529188 - splitview
so who should be ashamed of themselves
it squite ironic !
Isn't talking to ones self a form of madness
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:30 - 246 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529201 - in reply to msg. #529199 - splitview
fark u 2 fool ramper
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:35 - 242 reads
Posted by trade4profit
IP 144.139.xxx.xxx
Post #529204 - in reply to msg. #529197 - splitview
diatribe...
Here are the posts you refer to "6 - 8 weeks ago"...
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Subject copper strike.. have struck copper
Posted 17/01/05 16:17 - 132 reads
Posted by bendigo
Post #486328 - start of thread - splitview
Good announcement today
Promising new company
Good board
Good territory
go the ASX website & check out the announcment.
Cheers
Bendigo
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Subject re: copper strike.. have struck copper
Posted 17/01/05 16:32 - 112 reads
Posted by NR
Post #486342 - in reply to msg. #486328 - splitview
all ready on them bendigo......awaiting further annonucements.......
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Subject re: copper strike.. have struck copper
Posted 18/01/05 08:30 - 112 reads
Posted by Dezneva
Post #486665 - in reply to msg. #486328 - splitview
Yep, I agree. I know the people as well. They have a whole heap of old TEC ground. Its a great hit. and I think they are continuing the drilling.
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These were the first 3 posts ever on CSE.
Although Dezneva only posted "...I know the people as well...", I can see how you may have remebered that as "...the boss being a good bloke..."
Problem is, it was Bendigo he was replying to and not you!
How do you explain that?
Cheers!
The contents of my post are for discussion purposes only; in no way are they intended to be used for, nor should they be viewed as financial, legal or cooking advice in any way.
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:40 - 234 reads
Posted by Rocker
IP 220.253.xxx.xxx
Post #529215 - in reply to msg. #529204 - splitview
well picked up T4P
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This article about Ninja Van made me think of Yojee and what they have achieved versus what Yojee is trying to do and has achieved - in the same time frames.
https://www.cnbc.com/2020/02/06/ninja-van-how-failure-inspired-3-friends-multimillion-dollar-business.html
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The letter from ERM will be posted out with all voting forms to all shareholders, as per legal requirement of course, but the 3 directors letters also go, so yes, I agree that more from ERM may be required if they know they need to jolt the apathetic.
Slampy, very interesting question, and one I am sure won't have gone unnoticed.
Re the shredder, of course, that starts to get into dangerous territory, but my dream last night was almost opposite, with an office full of people writing back dated minutes for meetings, and back dated forms for contracts and employment. It was a hectic dream, and I hope there's no reality in it at all.
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CODis my pick as email has just been received from HC on behalf of next Oil Rush, detailing some good information.
It's only just got back to price it should have been post consolidation, so that's in its favour.
Very little to sell, I like that, as it will move quickly.
Many won't have received the email yet as they're at work, etc.
Read more here.
http://www.nextoilrush.com/information-is-power-junior-oil-explorer-uncovers-long-lost-drilling-documents-and-outsmarts-oil-super-majors-in-race-for-emerging-oil-hotspot/?utm_source=HCMO
Looks good for next week. Be prepared!- *Removed* this post has been removed from public view
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Salty - howsabout an email update please imo!!- *Removed* this post has been removed from public view
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Is PYC's share price going to behave like NEU before and after FDA approval?
In a nutshell, yes, but much better! The devil's in the detail.
Yes, the devil is very much in the detail.
To sell or not to sell one of the drug assets in the pipeline?
NEU sold its North American distribution rights for their Rett syndrome drug Trofinetide to Acadia in 04/2023, to be marketed as DAYBUE
It was in in August, 2018 that Neuren licensed North American rights for trofinetide to Acadia and received just US$10m upfront. The market hated the deal (low upfront, not a Big Pharma) and the share price subsequently suffered.
HOWEVER, the deal meant that Neuren didn’t have to pay for Phase 3 trials and regulatory and marketing expenses.
Acadia’s external provider R & D costs alone for trofinetide, as recorded in the company’s SEC filings, totalled ~US$212m (A$327m) as at 31/12/23. That doesn’t include internal R & D costs, any upfront or milestone payments or any commercialisation costs for the drug.
https://ir.acadia.com/sec-filings/
Who is making more money - NEU or Acadia?
So NEU is only getting A$12.8M out of the 4th Quarter sale of A134M, i.e. 9.55% in royalty. Is that a good deal ???
At first glance, this suggests that Neuren’s financial benefit from the Acadia licensing deal is limited to 9.55 % royalties on sales, with Acadia creaming all the rest. This is absolutely not the case.
The North American licensing deal with Acadia for trofinetide provided for:
- US$10m (A$15m) upfront
- US$40m (A$60m) on first commercial sale in North America
- Tiered royalties of 10% on net sales < US$250m, 12% on net sales US$250m - $500m, 14% on net sales US$500m - $750m, 15% on net sales >US$1bn.
- Sales milestone of US$50m (A$75m) on annual net sales >US$250m
- Sales milestone of US$50m (A$75m) on annual net sales >US$500m
- Sales milestone of US$100m (A$150m) on annual net sales >US$750m
- Sales milestone of US$150m (A$225m) on annual net sales >US$1bn
- One third of the value of Priority Review Voucher granted (est. 1/3 of US$100m = US$33m (A$50m)
- All R & D costs paid by Acadia. As stated above, expenditure on external provider costs alone had totalled US$212m (A$327m) by 31/12/23
https://hotcopper.com.au/threads/ann-agm-chair-address-ceo-presentation.7406476/
The Rest of the World licensing deal with Acadia for trofinetide provided for:
- US$100m (A$150m) upfront
- US$35m (A$53m) on first commercial sale for Rett indication in Europe
- US15m (A$23m) on first commercial sale for Rett indication in Japan
- US$10m (A$15m) on first commercial sale in 2nd indication in Europe
- US$4m (A$6m) on first commercial sale in 2nd indication in Japan.
- Sales milestones of up to US$170m (A$255m) in Europe
- Sales milestones of up to US$110m (A$165m) in Japan
- Sales milestones of up to US$83m (A$125m) in other territories
- Tiered royalties on net sales from mid-teens to low 20s %
https://hotcopper.com.au/threads/an...d-global-partnership-for-trofinetide.7478191/
All of this information needs to be taken into account before deciding whether Neuren got a good deal.
Recent major events and their effect on NEU's SP:
- 23/03/2020 dropped to 1X @ 0.97Share price artificially pushed down for accumulation on confirmation of Phase 3trail timetable and details
Yes, the share price dropped to just $0.97 in late March 2020, leaving NEU with a market cap of just $100m, despite having its lead drug in Phase 3 trials with those trial costs being paid by someone else.
There were two (related) reasons for the share price drop in March 2020.
The first was the general sharp drop in the markets at this time as the world suddenly started to shut its borders due to Covid. The ASX small cap index fell 35% in just one month.
The other reason was that Neuren’s erstwhile long-time largest shareholder, the late Lang Walker, dumped his entire holding (17.8%) in two tranches, the second largest tranche (14m shares) at just $1 per share. The sale of the second tranche was announced by the Company on 26/03/20 and the share price bottomed the following day @ $0.965.
- 08/12/2021 8X@ 3.85DAYBUE (Trofinetide) forRett syndrome Phase 3shows stunning efficacy [It took 22 months to do a12-month trial due to Covid]
https://classic.clinicaltrials.gov/ct2/history/NCT04181723?B=10&A=1&C=merged#StudyPageTop
Observations:
- Adding the 2nd drug's good Phase 2 efficacy caused SP to be nearly another 2X (or 24X from baseline) ****** Note that the BIG JUMP in SP is due to the fact that the Phelan-McDermid drug is 100% owned by NEU. Whereas the Rett syndrome drug is already sold to Acadia and NEU is only earning % royalty. Now you would appreciate selling the crown jewel is not a good idea and a Cap Raise is painful and dilutive, but it's only a short term pain for long term gain!
Yes, the NEUshare price almost doubled on announcement late last year of Phase 2 success of Neuren’s second drug, NNZ-2591 in Phelan McDermid syndrome, a drug which it fully owns (except in Rett syndrome and Fragile-X).
But the share price also (more than) doubled on Phase 3 success for trofinetide, for which Neuren had already sold US rights.
Further contributing factors to the great market response to NEU's Phase 2 PMS results were
- the results were exceptionally strong, stronger than those seen in trofinetide.
- as NEU was simultaneously conducting Phase 2 trials of NNZ-2591 in 3 other indications, targeting similar symptoms, the assessed likelihood of success in those 3 other indications increased, multiplying the effect of the announcement on share price.
PYC Valuation:
If all goes well, the ADPKD drug would be commercialized in 2028 with an estimated recurring annual earnings of US$10b.
PYC has indicated the possibility of commercialization of its drug for ADPKD in 2029, based on accelerated approval. FDA has been tightening the rules on accelerated approval. It is demanding that a Phase 3 trial already be well underway before it will consider allowing the accelerated approval pathway to be used. Thus the very time-consuming Phase 3 trial preparation, manufacturing and initial recruitment has to be completed (and paid for) well before any money flows into the coffers from commercial sales.
Also, while the estimated market for ADPKD might be US$10b and it is true that current treatment for the disease is inadequate, there are multiple other PKD therapies in development around the world, with a number of them already well into clinical trials. If PYC succeeds in this indication, it is highly unlikely that it will be the only drug to do so.
Therefore, it would be naïve to assume that PYC would have, and/or continue to have, that US$10bn market to itself.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329410/
https://news.mit.edu/2024/new-drug-candidate-can-shrink-kidney-cysts-0122
https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/240229-150000.html
I’m not wishing to sound negative on PYC; longer term holders here will know that I am actually bullish.
But PYC is not 18 months behind NEU. NEU has a commercialised drug on the market, whereas PYC is at least 4 years away from that milestone.
Further, even after Neuren achieved successful results in Phase 3, it should be noted that the Company’s market cap rose to just slightly more than where PYC’s market cap already sits.
The extreme growth in NEU’s share price occurred in part because it came off an extremely low base market cap of just A$100m when it was already in Phase 3.
That extremely low market cap was mainly the result of the largest shareholder dumping his stock @$1 just as COVID hit. NEU shareholders didn’t see either of those events coming.
There will be varying opinions about whether NEU did well or got ‘dudded” in its licensing deal with Acadia for trofinetide. But, when forming an opinion, one should consider the full impact of the deal, in terms of both revenue and expenditure. And that also applies in any consideration of whether PYC should outlicense or go it alone. -
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Lots of reading today!
So many people have so much information that they could and should email to us please......
[email protected]
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Last
$1.15 |
Change
-0.050(4.17%) |
Mkt cap ! $670.7M |
Open | High | Low | Value | Volume |
$1.18 | $1.20 | $1.15 | $146.7K | 125.4K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
6 | 71742 | $1.15 |
Sellers (Offers)
Price($) | Vol. | No. |
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$1.20 | 11949 | 2 |
View Market Depth
No. | Vol. | Price($) |
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6 | 71742 | 1.150 |
1 | 50000 | 1.140 |
1 | 6756 | 1.130 |
1 | 889 | 1.125 |
3 | 9261 | 1.100 |
Price($) | Vol. | No. |
---|---|---|
1.200 | 11949 | 2 |
1.205 | 2270 | 1 |
1.210 | 6000 | 1 |
1.220 | 5596 | 2 |
1.230 | 15000 | 1 |
Last trade - 16.10pm 18/06/2025 (20 minute delay) ? |
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