Another way of looking at the potential within the macrocycle...

Another way of looking at the potential within the macrocycle sector is to think about it as frontier science;

"While much of the excitement over macrocycles is due to their potential to disrupt intracellular protein-protein interactions, every currently disclosed lead program in the space targets an extracellular protein. This reality reflects the challenge of developing a potent and cell-penetrant macrocyclic compound," said Chris Cain, Excited about Cycling.

Early success will be rewarded. When the breakthrough does come and the 'code is cracked' for cell permeability and oral availability then the scientific world will be at the door step.

I find particularly interesting the observation that most of the existing macrocycle drugs are naturally occurring or analogs of naturally occurring molecules. This is one of Phylogica's key advantages with its libraries of natural peptides particularly with the development of second generation libraries which focus upon invasive pathogens to exploit "all the major endocytotic pathways for cell entry".

Wayne.