PYC - General Discussion, page-657

First 657 Last

Share
Profile

Follow
hottod

6,291 Posts.

22313

28/11/24

10:25

Post #: 76816959
Share

Originally posted by Fat Harrys Cat ↑

I’m not a medic, but in the NHP the treatment related adverse effects begin somewhere between 12 mg/kg and 30 mg/kg.
So I’d assume the Phase 1 human trial (healthy volunteers) might start at 3 mg/kg and go to 9 and 12 if they have 3 cohorts? Or maybe they’ll just have 1 cohort and use the next phase as a dose range-finder?
A brief skim of the results shows that PYC003 concentration increases from the dose of 3 mg/kg to about 500 mg/g in the target tissue. That’s an increase in concentration of about 165 times. So no wonder the 30 mg/kg dose produced some TRAE.

All in all I’m excited about this. This thing is a sleeping giant IMO.

Expand

FHC, the anticipated therapeutic dose in humans will be just 0.8-3.0 mg/kg.

Well, well below the 30mg/kg dose that wasn’t tolerated and still well below the 12mg/kg dose that demonstrated no adverse effects.

PYC Price at posting: $1.97 Sentiment: Hold Disclosure: Held
18 Upvote

1 Great analysis

Reply

Top Stories

Almonty Industries – Now it is getting critical!

ASX Market Open: Shares down as Trump threatens 'real end' to Israel-Iran conflict | June 18

MEM

Many are concerned about global falling birthrates. This diverse stock has solutions

Listen: HotCopper Wire Podcast 013 - They changed the IPO rules (and that's a good thing)

LU7

Lithium Universe leaps 40% after buying rights to flashy solar panel recycling tech

First 657 Last

Add to My Watchlist

What is My Watchlist?

A personalised tool to help users track selected stocks. Delivering real-time notifications on price updates, announcements, and performance stats on each to help make informed investment decisions.

(20min delay)
Last $1.18		Change -0.020(1.67%)		Mkt cap ! $688.2M

Open	High	Low	Value	Volume
$1.18	$1.20	$1.17	$38.41K	32.52K

Buyers (Bids)

No.	Vol.	Price($)
3	15347	$1.18

Sellers (Offers)

Price($)	Vol.	No.
$1.20	7625	1

View Market Depth

No.	Vol.	Price($)
3	15347	1.175
3	4126	1.170
1	3269	1.165
2	5683	1.160
2	9513	1.155

Price($)	Vol.	No.
1.195	7625	1
1.200	19368	5
1.205	2453	2
1.210	7117	2
1.220	7276	3

Last trade - 13.27pm 18/06/2025 (20 minute delay)

PYC (ASX) Chart

PYC - General Discussion, page-657

Almonty Industries – Now it is getting critical!

ASX Market Open: Shares down as Trump threatens 'real end' to Israel-Iran conflict | June 18

Many are concerned about global falling birthrates. This diverse stock has solutions

Listen: HotCopper Wire Podcast 013 - They changed the IPO rules (and that's a good thing)

Lithium Universe leaps 40% after buying rights to flashy solar panel recycling tech

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

PYC - General Discussion, page-657

Top Stories

Almonty Industries – Now it is getting critical!

ASX Market Open: Shares down as Trump threatens 'real end' to Israel-Iran conflict | June 18

Many are concerned about global falling birthrates. This diverse stock has solutions

Listen: HotCopper Wire Podcast 013 - They changed the IPO rules (and that's a good thing)

Lithium Universe leaps 40% after buying rights to flashy solar panel recycling tech

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News