Stoke Therapeutics has announced new data from two open-label Phase 1/2a studies and two open-label extension studies of its lead antisense therapy, STK-001, in children aged 2-18 years with Dravet syndrome. Dravet is a rare genetic epilepsy syndrome caused by haploinsufficiency.
The latest results showed substantial and durable reductions in convulsive seizure frequency (up to an 85% reduction 3 months after the last of 2 or 3 doses of 70mg) as well as improvements in multiple measures of cognition and behaviour. Two patients were seizure free at 3 and 6 months.
The improvements were seen in a highly refractory group of patients who were already taking the best available anti-seizure medicines. 85% of patients were routinely being treated with 3 anti-seizure medications.
STK-001 was generally well-tolerated. In the Phase 1/2a studies, 30% (24/81) of patients experienced a treatment-emergent adverse event that was related to the study drug. The most common were CSF protein elevations and procedural vomiting.
The Company plans to meet with regulatory agencies to discuss a registrational study that includes initial doses of 70mg followed by continued dosing at 45mg.
Stoke Therapeutics’ (STOK:NASDAQ) stock price quickly doubled on the news, finished the day 58% up as the Company announced a US$75m public offering.
https://finance.yahoo.com/news/stoke-therapeutics-announces-landmark-data-200100436.html
https://www.neurologylive.com/view/...cts-in-early-phase-studies-of-dravet-syndrome
https://www.fiercebiotech.com/biote...-epilepsy-drug-reduces-convulsive-seizures-43
- Forums
- ASX - By Stock
- PYC - General Discussion
Stoke Therapeutics has announced new data from two open-label...
- There are more pages in this discussion • 105 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add PYC (ASX) to my watchlist
(20min delay)
|
|||||
Last
10.5¢ |
Change
0.005(5.00%) |
Mkt cap ! $489.9M |
Open | High | Low | Value | Volume |
10.0¢ | 10.5¢ | 10.0¢ | $159.5K | 1.534M |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
11 | 1048558 | 10.0¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
10.5¢ | 1474495 | 4 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
11 | 1048558 | 0.100 |
4 | 192124 | 0.099 |
5 | 147383 | 0.096 |
11 | 886419 | 0.095 |
1 | 10860 | 0.093 |
Price($) | Vol. | No. |
---|---|---|
0.105 | 1474495 | 4 |
0.110 | 758401 | 8 |
0.115 | 583218 | 6 |
0.120 | 1103314 | 10 |
0.125 | 2190479 | 7 |
Last trade - 16.10pm 04/06/2024 (20 minute delay) ? |
|
|||||
Last
10.5¢ |
  |
Change
0.005 ( 4.69 %) |
|||
Open | High | Low | Volume | ||
10.3¢ | 10.5¢ | 10.0¢ | 885924 | ||
Last updated 15.50pm 04/06/2024 ? |
Featured News
PYC (ASX) Chart |