SoTI have no medical background and I needed to get a bit more...

SoT
I have no medical background and I needed to get a bit more background on the information in your post.

Here is a link which others may find helpful.

https://www.sciencedirect.com/topics/neuroscience/progranulin

Exciting developments. It will be interesting to see if it is effective on
1. Pure PLS
2. Hereditary related ALS.
3. Non hereditary ALS.

would seem to only improve performance of the upper neurons in the brain and not the lower neurons in the spine.

Thanks to posters like yourself and Hottod et al whose posts are invaluable for the uninitiated like myself.