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12:25
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Originally posted by RaceOncology:
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There does appear to be differences is FTO variants between different human populations, but that does not matter for what we are doing in this trial. We are not measuring FTO activity directly, but the level of m6A in the RNA before and after treatment with bisantrene. We are looking to see if bisantrene changes the m6A in levels in RNA (we expect that it would increase), not inhibition of FTO directly.
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Does the FTO/m6A system function similarly in animals as it does in humans? If so has Race looked at Bisantrene's effect on m6A levels in any of the animal studies that have been performed? If not, why not?
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