The July sequence from San Paulo is the most recent pandemic H1N1 sequence released to date.
Most of the other sequences are from isolates in April, May, and early June.
The characterization sheet indicates this isolate came from an 11 year old girl who was fatally infected with H1N1. Only the HA (codes for the H1 in H1N1) sequence was released, and it has three changes. The travel logs listed show which other sequences in the data base have that change.
However, for the bottom line, V252M may allow the virus to escape from the vaccine being developed, because that change is important in influenza B immunologoical recognition and may be one of the reasons half of the time the influenza B vaccine is a mis-match.
However, apart from the vaccine issue, this change was present in the 1918 pandemic strain (as represented by the three 1918 HA sequences in the database).
The 1918 pandmeic strain combined pieces from H1N1 seasonal flu with H1N1 swine flu, and V252M is found in seasonal flu (2006 isolates from Peru) as well as early (pre-1957) seasonal H1N1. It is also in swine H1N1, so the profile for V252M is not a good one.
The otehr two changes are in 2009 pandmeic isolates, but in different sets of isolates signaling recombination, which is what is used to jumble up the changes to create novel sequences with new properties.
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